McMiror complex, supp vag. 500 mg No. 8 (Doppel Pharmaceutical S.r.L., ITALY)

In gynecology, suppositories are used for local therapy. They are considered convenient for placement in natural cavities, and also deliver the drug directly to the pathological focus. Suppositories can be prescribed for pain relief, inflammation relief, tissue and flora restoration, and immune stimulation.

Macmiror suppositories can be prescribed for pain relief, inflammation relief, tissue and flora restoration.

Macmiror suppositories are indicated for various types of infections. The extended effects of the drug - antifungal, antibacterial, antiprotozoal - are justified by the composition.

pharmachologic effect

Medicines of the nitrofuran series are highly active and are able to cleanse the body of pathogenic microorganisms, most protozoan parasites, and Candida fungi.

Nifuratel, on which Macmiror's pharmaceutical formula is based, is capable of suppressing up to 94% of cultures.

In the treatment of trichomoniasis, nifuratel has a detrimental effect on the fungal and bacterial flora that maintains inflammation (vaginitis).

The antibiotic nystatin not only complements, but also strengthens the connection. As a representative of the group of polyenes, nystatin destroys fungi at the cellular level.

With low toxicity, the combination exhibits a pronounced effect. At the same time, the physiological flora of the vagina is not disturbed.

Compound

The therapeutic components are the antimicrobial component Nifuratel , which inhibits the proliferation of protozoa, and the antifungal agent Nystatin. Auxiliary ingredient: Dimethicone silicone oil. The medicinal substances are enclosed in a glycerin-gelatin capsule, which dissolves in the vagina. Inside the shell there is an oily content.

Important!

The active components of Macromiror are Nystatin and Nifuratel, which inhibit the development of bacteria, protozoa and pathological fungi.

Release forms and composition

Patients can purchase Macmiror for intravaginal use in the form of suppositories or cream. Both forms have similar compositions.

The blister contains 8 or 12 candles, they are orange. Packaged together with instructions for use in a cardboard box.

McMiror complex, supp vag. 500 mg No. 8 (Doppel Pharmaceutical S.r.L., ITALY)

Composition and release form.

30 g of cream in an aluminum tube complete with an applicator (graduated syringe) and instructions for use are placed in a cardboard box.

the blister contains 8 or 12 vaginal suppositories; 1 blister with instructions for use is placed in a cardboard box.

Characteristic.

A combined drug for topical use in gynecology, consisting of a nitrofuran derivative (nifuratel) and a polyene antibiotic (nystatin).
Pharmachologic effect. Antibacterial, antiprotozoal, antifungal.

Pharmacodynamics.

Active against Trichomonas vaginalis

and fungi of the genus
Candida,
protozoa, gram-positive and gram-negative microorganisms.

Clinical pharmacology.

Antimicrobial drug for topical use. It has antiprotozoal, antifungal and antibacterial effects.

Nifuratel, a derivative of nitrofuran. Highly active against a number of bacteria, fungi and protozoa (including Trichomonas vaginalis

).

Nystatin is an antifungal antibiotic of the polyene group. By binding to sterols in the cell membrane of fungi, it disrupts its permeability, which leads to cell death. Highly active against fungi of the genus Candida albicans.

The combination of nifuratel and nystatin allows one to achieve a more pronounced antifungal effect and significantly expand the spectrum of antimicrobial action.

The high efficiency and low toxicity of the components of the drug determine a wide range of its clinical use in the treatment of vaginitis of mixed etiology, in particular, use for the prevention of mycoses caused by the specific treatment of trichomoniasis.

Macmiror complex does not disturb the physiological flora, which allows you to avoid the development of dysbacteriosis and quickly restore vaginal normocenosis.

Indications.

Complex therapy of vulvovaginal infections caused by pathogens sensitive to the drug: bacteria, trichomonas, fungi of the genus Candida

and chlamydia.

Contraindications.

Hypersensitivity to one of the active ingredients or any auxiliary ingredient of the drug.

Use during pregnancy and breastfeeding.

There are no contraindications to the use of the drug during pregnancy and lactation (breastfeeding).

Side effects.

In rare cases, allergic reactions in the form of skin rash or itching are possible.

Interaction.

No clinically significant interaction of the drug Macmiror complex with other drugs has been established.

Method of administration and dose.

Intravaginally

, before bedtime - for 8 days, 1 supp. or 2.5 g of cream 1-2 times a day (using an applicator). If necessary, treatment is repeated after menstruation.

To achieve the maximum therapeutic effect, the suppository should be inserted into the upper part of the vagina.

Suppositories are not used for treatment in childhood; it is recommended to use vaginal cream complete with an applicator (graduated syringe).

Special instructions.

It is necessary to simultaneously treat the sexual partner due to the risk of re-infection. During treatment with the drug, sexual contact should be avoided.

Method of using a graduated applicator: screw the graduated applicator onto the tube of cream. Take the required amount of cream (in accordance with the scale lines indicating the amount in grams) by pressing on the tube. Disconnect from the tube, insert into the vagina, squeeze out the contents by pressing on the rod.

The presence of a special nozzle allows you to introduce the cream without damaging the hymen. To do this, you need to remove the cannula from the top of the shaft and screw it onto the head of the syringe from the opposite side before inserting the cream into the vagina.

Conditions for dispensing from pharmacies.

On prescription.

Special instructions for use and precautions

During the period of taking the medicine, sexual relations are strictly prohibited. Both partners should be treated for infectious STDs.

In pediatric practice, suppositories are not used. For the treatment of diseases of the genitourinary system in girls, Macmiror cream is recommended; it is sold complete with a graduated applicator.

For the treatment of diseases of the genitourinary system in girls, Macmiror cream is recommended.

Purpose

Suppositories are intended for women over 18 years of age for the purpose of complex treatment of the following vaginal pathologies :

• candidiasis, called thrush;
• trichomoniasis, affecting the urogenital system;
• urethritis and cystitis;
• chlamydia;
• vaginal dysbiosis.

The drug is in demand in situations where it is necessary to prevent the development of vaginal pathologies. Studies of the drug have not been conducted on girls, so Macmiror is not recommended for use by minors.

Important!

Vaginal suppositories are intended for the treatment of diseases of the vagina in women over 18 years of age.

Analogs

Macmiror Complex has a complex composition. It is possible to replace suppositories containing nifuratel and nystatin only with several different drugs, because these substances enhance each other's effects.

But if the replacement is due to the fact that Macmiror is expensive, then you can easily find suppositories cheaper.

But if the replacement is due to the fact that Macmiror is expensive, then you can easily find suppositories cheaper, but their antimicrobial or antifungal effect is ensured by other substances.

Betadine

Povidone-iodine capsules. In gynecology, they are indicated for the treatment of fungal and microbial infections.

The antiseptic and disinfectant has a wide range of contraindications.

With prolonged or repeated use, the therapeutic effect is reduced. Cost – up to 350 rubles.

Iodoxide

The active substance is the same as Betadine. The impact is softer, cheaper by 100 rubles.

The drug Iodoxide costs 100 rubles less than Macmiror.

Povidin

Another drug based on povidone-iodine. Involves a long therapeutic course. The cost is less than 200 rubles.

Hexicon

Chlorhexidine bigluconate is a substance that provides the antiseptic effect of Hexicon. The choice for patients is wide - there are tablets, vaginal suppositories and even a solution for external use (irrigations, rinses, lotions).

Application is limited, because Some fungi and viruses are resistant to chlorhexidine.

Prescribed for vaginitis, cervicitis. As a preventive measure against STDs, it is administered within 2 hours after sexual intercourse. There are no contraindications. The cost is a little more than 300 rubles. (10 supp.), individual packaging available - 50 rub. for 1 supp.

Osarbon

According to the pharmacological group, it is classified as an antiprotozoal agent. The indication is Trichomonas colpitis. The therapeutic effect is based on osarsol, but the focus of the medicine is narrow. Also contains boric acid and glucose. Causes dermatitis and fever, which requires discontinuation of the therapeutic course. Contraindicated for pregnant women. Cost 10 supp. – about 120 rub.

Application

The use of Macmiror in the form of suppositories is allowed for the following pathologies:

• thrush,
• chlamydia,
• trichomoniasis,
• cystitis, urethritis,
• vaginal dysbiosis,
• prevention.

General provisions

Instructions for use recommend inserting the suppository deep into the vagina before bed after water procedures.
The course of treatment is 8 daily injections. Before the procedure, you should not irrigate the vaginal walls with aqueous soap solutions. After inserting the suppository, it is best to sleep on your back to avoid leakage of the medicine. Therapy is carried out under the supervision of a doctor, who may recommend extending the course to 14 injections.

This is interesting! How to use Methyluracil suppositories: instructions for use in gynecology

It is prohibited to use the drug during menstruation as the expected therapeutic effect will not be achieved. It is necessary to calculate the moment when it will be possible to begin therapeutic procedures. After the next critical days, the doctor conducts a gynecological examination . If there are indications for continuing treatment, the gynecologist prescribes a second course of tablets or cream.

Important!

Macmiror suppositories are inserted before bedtime for 8 evenings in a row.

During treatment it is necessary to stop intimate life. The use of alcohol is contraindicated. If a protozoal or fungal disease is diagnosed, regular sexual partners are required to undergo treatment with an oral medication or cream.

The drug Macmiror during pregnancy is used when the fetus reaches 20 weeks of age . The absorption of the active principles of the vaginal mucosa is negligible, but the absorbed amount may be sufficient to harm the fetus during the formation of internal organs. The use of the medicine in the second half of gestation takes place under close medical supervision. When breastfeeding, it is necessary to monitor the baby, and at the first negative signs the drug is discontinued.

Important!

Pregnant and lactating women should use the drug with caution.

Treatment of thrush

Macmiror for thrush is recommended for use from the moment the disease is detected. In addition to suppressing the generation of Candida fungus, the drug inhibits the development of secondary bacterial and protozoal microflora. Before use, an examination is carried out to determine the absence or presence of contraindications. They consist of congenital disorders of the absorption of monosaccharides, as well as personal intolerance to the ingredients of the drug.

Doctors do not recommend using tableted Macmiror for thrush, because in this situation it passes into breast milk.

Important!

Before starting treatment for thrush, the woman is examined for the absence of contraindications and sensitivity to the ingredients of the drug.

Chlamydia

Contagion is transmitted through coitus.
In women, rickettsia causes inflammation, which leads to infertility or miscarriage. If the baby is born, it will be infected. In men, chlamydia can reduce potency, cause inflammation of the prostate and lead to infertility. If a pathogen is detected by PCR of a vaginal smear or blood ELISA, both regular partners are treated.

Although the absorption of the active components of the drug from the vaginal mucosa is minimal, doctors do not risk prescribing treatment with suppositories before the twenty-week gestation period. During lactation, suppository therapy is also carried out under medical supervision. Treatment consists of 10-12 vaginal injections of suppositories.

Trichomoniasis

The diagnosis is confirmed by examining a vaginal smear using PCR. Antiseptic suppositories are inserted before bedtime. The course of treatment is almost the same as for chlamydia.

Important!

If Chlamydia or Trichomoniasis is suspected, a reliable way to identify the pathogen is to examine a vaginal smear using PCR.

Cystitis, urethritis

Suppositories are administered according to the classical scheme: daily insertion of 1 suppository into the vagina for 8 evenings in a row.

Prevention

After a course of treatment, the doctor prescribes preventive procedures to avoid relapses. They are carried out according to the classical scheme - 8 evening administrations in a row.

Reviews

Larisa, 34 years old, Magadan: “I got such a cold last winter that I was admitted to a hospital ward. After discharge everything was fine for some time. But no one is immune from relapse. I treated another inflammation on the recommendation of a gynecologist with Mikmiror suppositories. Small, convenient, but relieve symptoms quickly and efficiently. In order not to stain the laundry, I used “daily bags”; I had experience with leaking orange candles before.”

Angelina, pharmacist at the Klever pharmacy, St. Petersburg: “Makmiror suppositories have a safe composition. I had a chance to use them myself. I believe that women should have this product in their home medicine cabinet. It copes well with thrush and other vaginal diseases. They have no odor, are easy to administer, and an 8-day course is more than enough. The cost is justified."

Pharmacological properties

Pharmacodynamics.
The drug Makmiror complex is a combination drug with the active ingredients nifuratel and nystatin. nifuratel is a chemical medicinal substance synthesized by the poli research laboratory, effective against trichomonas, bacteria and fungal microorganisms. Nystatin is an antifungal antibiotic that is effective in the treatment of candidomycosis.

The combination of nifuratel and nystatin has an effective effect on fungi, trichomonas and bacteria, while the interaction of the two active substances does not have negative effects, and they complement and enhance the antifungal effect of each other.

Pharmacokinetics. The substances included in the drug are not absorbed by the soft tissues of the body and do not have a systemic effect.

Note!

Description of the drug Macmiror Complex caps. vagina. No. 8 on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.

special instructions

Use of the drug, especially for a long time, may cause hypersensitivity reactions. If signs of an allergic reaction occur, you should stop using the drug.

While using the drug, you must abstain from sexual relations. It is necessary to simultaneously treat the sexual partner to avoid re-infection.

During pregnancy and breastfeeding. It is not recommended to use the drug during pregnancy. During treatment you should stop breastfeeding.

Children. The drug is not used in children.

Impact on the ability to drive vehicles or operate other machinery. The drug does not affect the ability to drive vehicles or operate machinery.