About Monural
Monural is used for the treatment of acute bacterial inflammation of the bladder, urethritis, massive bacteruria, and the prevention of postoperative complications. Its advantage is the ability to maintain a high therapeutic concentration due to enterohepatic circulation for a couple of days after administration. You can drink one sachet of Monural, diluted in water, to get rid of unpleasant symptoms. A single dose is usually sufficient. But a second dose may be required if the symptoms do not go away after the first use.
The medicine is taken on an empty stomach. It is also advisable to empty your bladder in advance. After 2–2.5 hours, the highest concentration of the active substance appears in the blood. The effect lasts for 2 days. During this time, patients note the complete disappearance of symptoms. Pain is eliminated, urine color and consistency are normalized, and body temperature decreases.
The use of Monural in Russia and other countries has proven its effectiveness and safety for pregnant women, children and the elderly.
High efficiency and the absence of the need to take a large dose are the positive aspects of Monural. That is why doctors so often prescribe it. But there are also similar medicines that are no less effective, but at the same time have a lower price.
Monural: instructions for use
According to the instructions, the drug is intended for oral administration. The granules are diluted in 60-70 ml of water at room temperature. Take the antibiotic before meals 2 hours or after. It is better to drink before going to bed, having gone to the toilet beforehand.
The dosage and duration of the course of therapy directly depends on the form of the pathology and the age of the patient.
Adult patients are prescribed a one-time dose of 3 g. In severe cases of the disease, the dose can be doubled. The patient is then given 3 g again after 24 hours.
To prevent infectious processes of the urinary tract due to operations, it is recommended to use the medicine 3 hours before surgery, and a day after it in the amount of 3 g.
In children over 5 years of age, the drug is prescribed once a day, 2 g.
In case of disorders of the excretory system, the therapeutic dose must be adjusted.
Analogues by mode of action
There are analogs of Monural that have a similar effect on the body, but are cheaper than the original. That's why patients choose them.
Amoxicillin
Amoxicillin is an antibiotic with a broad spectrum of action. It is produced in granules. This remedy helps in the treatment of infectious pathologies caused by bacteria.
The drug is quickly absorbed. Amoxicillin is a semi-synthetic antibiotic, so it should only be used as prescribed by a doctor.
Indications for use:
- cystitis;
- intestinal infections;
- pneumonia;
- pyelonephritis;
- pharyngitis;
- gynecological infections.
This medicine has contraindications. These include:
- ARVI;
- lymphocytic leukemia;
- allergic reactions.
It is forbidden to use this medicine during breastfeeding.
Nolitsin
This is a cheap analogue of the drug Monural for cystitis. Its active substance is norfloxacin. The medicine is available in tablet form and is recommended for the treatment of inflammatory processes occurring in the pelvis and having an infectious nature. The use of the drug is contraindicated in case of individual intolerance to its components, pregnancy, lactation, as well as in children under 18 years of age.
Nolicin is prescribed for the treatment of cystitis, urethritis, as well as infectious pathologies in the genitals and intestinal infections. Patients note that when using it, the symptoms of the disease disappear quickly.
Urolesan
This is a drug with a herbal composition. It is produced in glass bottles of 15 ml, as well as in the form of capsules and tablets. The active substance in it is Trilon-B, as well as essential oils.
Urolesan has proven itself well in the treatment of cystitis, urolithiasis of the gallbladder and bladder, in the treatment of pyelonephritis, cholecystitis. It can be taken by both adults and children. The drug is well tolerated, however, in case of high sensitivity to its components, the use of this medicine is not recommended. The instructions for the medicine indicate the following contraindications: stomach ulcer, glomerulonephritis, gastritis.
Urfocin
This substitute for Monural helps in the treatment of cystitis and other uncomplicated inflammations of the urinary tract. It is also recommended for preventive purposes during diagnostics and surgical interventions.
Patients tolerate Urfocin well, but it is not recommended to take it if you are sensitive to any components of the drug. It is also not recommended for children and pregnant women.
Phytolysin
This is a good herbal preparation that contains herbal extracts and essential oils. It is used in the treatment of chronic pathologies of the urinary tract. Phytolysin has antimicrobial and anti-inflammatory effects. It quickly relieves the symptoms of cystitis.
It is produced in the form of a paste, which is taken orally. Medicines are prescribed for acute and chronic infectious diseases of the urinary tract. Phytolysin is made from plant components, but has contraindications. It should not be used by pregnant women and children. Also, taking the medicine is not recommended for people suffering from acute nephritis or nephrosis.
Furadonin
This is an antimicrobial synthetic medicine with a large area of action. Furadonin is not classified as an antibiotic. The medicine is used to treat infectious inflammation of the urinary tract.
It is available in the form of tablets, suspension, and powder. Furadonin is prescribed for the treatment of the following diseases:
- cystitis;
- pyelonephritis;
- urethritis.
In addition, this drug may be prescribed during certain diagnostic and surgical procedures, as well as for preventive purposes.
Furadonin should be taken only with a doctor's prescription, because this medicine has a number of contraindications:
- individual intolerance to components;
- renal failure;
- liver cirrhosis and others.
Small children under one month of age should not take this medicine.
Composition and release form
The drug is dispensed in the form of homogeneous granules for further preparation of parenteral solution. White powder with a pleasant fruity aroma. Packaged in multi-layer bags and a secondary paper pack with attached instructions for use. One package contains 1-2 packets of various volumes of product:
- Laminated sachets containing 3.7 g trometamol fosfomycin and 2 g fosfomycin.
- Laminated packets containing 5.6 g of fosfomycin trometamol and 3 g of fosfomycin alone.
The active ingredients of the drug are fosfomycin trometamol and fosfomycin in its pure form.
Additional components: sucrose, orange and tangerine flavors, saccharin.
The drug is dispensed only with a doctor's prescription.
Analogs for the active substance
There are inexpensive drugs that are made based on the same active ingredient as Monural.
We recommend that you read:
- Antibiotics for the treatment of cystitis.
- Medicines used for cystitis.
- Painkillers for the treatment of cystitis.
- Tablets for cystitis.
Ureacid
It is an antimicrobial and antibacterial drug with a wide range of action. It is prescribed for the treatment of infectious pathologies of the urinary tract, as well as for prevention during diagnosis and surgical interventions.
The medicine is made in the form of granules that are taken orally. Contraindications to taking this drug are allergic reactions to the components of the medication.
Urolysin
It is an anti-inflammatory, analgesic and diuretic drug made from herbal ingredients. It helps in the treatment of pathologies of the urinary tract and kidneys. It is more likely not a medicine, but a biologically active food supplement. It is prescribed for kidney stones, pyelonephritis, cholecystitis. It has a preventive effect, preventing the formation of stones.
This medicine is contraindicated in pregnant women and people with diabetes.
Urophosphabol
This is a Russian antibiotic that is prescribed to treat inflammatory processes caused by infection. It is prescribed for:
- infections in soft tissues;
- infectious pelvic inflammation;
- inflammation of the urinary tract.
Contraindications to the use of Urophosphabol are individual intolerance to the components of the drug, heart failure.
Fosmicin
This antibiotic is prescribed for the treatment of infectious inflammation of the lower urinary tract.
Pregnant and breastfeeding women should be careful when taking this medicine.
Fosfomycin
This is a drug that has an antibacterial effect. It is prescribed for infectious pathologies of the urinary tract.
The use of Fosfomycin is contraindicated if you are allergic to its components, as well as during pregnancy. It is not recommended for use in children under one year of age.
Fosfomycin trometamol
This is a drug with high antimicrobial activity and is taken orally. It is prescribed for the treatment of cystitis, as well as for the treatment of inflammatory processes in the acute stage. The medicine is taken once. For the treatment of chronic inflammation, therapy is extended to 10 days.
Fosfomycin has contraindications; consultation with a doctor is necessary.
Fosfomicin Esparma
This is an antibacterial drug with a wide spectrum of action. It comes in powder form and has a fruity scent. The medicine is used to treat inflammatory diseases of the lower urinary tract. The drug is taken orally. The medicine has contraindications: it is not recommended for pregnant women, children under 12 years of age, as well as persons who are highly sensitive to Fosfomycin.
Fosforal Rompharm
This is an antibiotic. He can completely replace Monural. Doctors prescribe it for the treatment of acute and mild inflammatory diseases of the genitourinary area. It also has a preventive effect during diagnostic procedures and surgical interventions.
A contraindication to its use is individual intolerance to the composition of the drug.
Ecofomural
This antibiotic is available in the form of granules, from which a solution is prepared for oral administration. Ecofuural is prescribed for the treatment of cystitis and other pathologies of the urinary tract. It is suitable for both adults and children over 12 years old.
The medicine has contraindications, so it should be used as prescribed by a doctor.
Reviews about Monural and its substitutes
Reviews about the use of the drug and its analogues are mostly positive. Patients note the high quality and effectiveness of analogues even from a lower price segment:
- Pavlenko A.S., urologist: “For urological infections, I prescribe Monural, but this is a rather expensive drug, and not all patients can undergo treatment with it. In such cases, I use analogues of Monural in treatment, for example Nitroxoline and Fosfomycin, which are much cheaper. Patients note the high effectiveness of substitutes.”
- Valentina, 60 years old: “I began to experience cystitis after menopause. I use Monural. The drug is highly effective; 1 dose is enough for me.”
- Evgeniy, 50 years old: “For pyelonephritis, I was prescribed Monural. I took the medicine 2 times at intervals of 24 hours, and after a week's break, another 1 dose. This drug helped me, I appreciate it for its effectiveness.”
Monural is an effective medication that is used in urology to treat sexually transmitted and urological infections. It is highly effective and does not cause many negative effects. It can only be used as prescribed by the attending physician.
Ukrainian analogues
Ukrainian pharmaceutical companies produce cheap and high-quality analogues of Monural. Here are the most common ones.
Dioxidine
This is an inexpensive Ukrainian-made drug, produced in the form of a powder from which a solution is prepared. The active substance Dioxidine has an antimicrobial effect. The drug is prescribed for the treatment of purulent infectious diseases of various types.
Dioxysol
This is an analogue of Monural, which has an affordable price, is manufactured in the form of a solution and is intended for the treatment of diseases caused by bacteria. This medicine has its own contraindications. It should not be used for arterial hypertension.
Uroxoline
This is one of the cheapest analogues of Monural. It is presented in tablet form and is used to treat genitourinary diseases. If kidney or liver function is impaired, this medicine is contraindicated.
Urofoscin
This is an antibacterial drug whose active substance is fosfomycin. It kills inflammatory agents. The drug should not be used by children under 12 years of age, as well as by patients with kidney or liver diseases.
Cystoral
This is an inexpensive analogue of Monural, produced in the form of granules for oral administration. It has an antimicrobial effect. Cistoral is prescribed for the treatment of mild genitourinary infections in the acute stage.
Foreign analogues
Substitutes for Monural, manufactured by foreign companies, have received good reviews from consumers. They have proven their effectiveness.
Kirin
This is an analogue of Monural, which is a tricyclic antibiotic. The active substance in it is spectinomycin, which has a pronounced antibacterial effect. Kirin is prescribed for the treatment of urinary tract infections.
Lizomac 600
This is one of the leading generics of Monural. It is produced in tablets and is used to treat various infections.
5-NOK (5-NOK)
This drug is very close to Monural, it is produced in tablet form. It is prescribed for the treatment of acute infectious inflammation of the genitourinary system. The medicine has some contraindications.
Fosmural
This is an effective antimicrobial medicine that helps in the systemic treatment of genitourinary infections. The active substance is fosfomycin.
Furamag
This is a Latvian drug, the main active ingredient of which is furazidin. Furamag has an antimicrobial effect, activates the immune system and increases the ability of leukocytes to capture harmful microorganisms.
Russian analogues
Russian manufacturers also produce inexpensive substitutes for Monural.
Bacteriophage Coli
This is a high-quality domestic drug that can easily replace Monural. It is produced in the form of a yellow solution. Its use is justified in the treatment of bacterial pathologies. A contraindication to the use of the drug is high sensitivity to its active components.
Calcex
This is one of the cheapest analogues. It is made in tablet form. Kalceks is used to prevent infectious pathologies. Contraindications to its use are pregnancy, liver dysfunction, and breastfeeding.
Nitroxoline
This is an inexpensive domestic substitute, which is presented in the form of tablets. It has proven itself well in the treatment of cystitis. The use of Nitroxoline is prohibited during pregnancy, lactation, as well as in cases of liver and kidney dysfunction.
Phosphocin
This is a cheap prototype of an analogue, manufactured in the form of soluble granules. It is used to treat uncomplicated inflammation of the genitourinary area. Contraindicated for children under 12 years of age.
Urophosphabol
This domestic analogue is produced in powder form. It is effective in treating diseases of a microbial nature.
Ureacid
Ureacid is an antimicrobial, antibacterial agent. Ureacid has a wide spectrum of antibacterial action. It is effective against strains of urinary tract infection pathogens, the most commonly isolated are: Escherichia coli, Citrobacter spp., Klebsiella spp., Proteus spp., Serratia spp., P. aeruginosa and Enterococcus faecalis - even if they are resistant to other antibacterial drugs. The drug also acts on penicillinase-forming strains. Ureacid has an anti-adhesive effect on bacteria that have the property of adhesion to the epithelium that lines the urinary tract. Pharmacokinetics. Ureacid is easily absorbed from the gastrointestinal tract, the maximum concentration in the blood plasma after 2:00 is 30-35 mcg / ml, the half-life is 2:00. Ureacid is not metabolized in the body; it is excreted by glomerular filtration in a biologically active form. Ureacid accumulates predominantly in the kidneys at a concentration of 2500-3500 μg/ml, and its minimum inhibitory concentration for Escherichia coli is 128 μg/ml. Enterohepatic circulation of Ureacid allows you to maintain a therapeutic level of the drug for 48 hours, this time is sufficient for sterilization of urine and recovery. Indications for use: Indications for use of the drug Ureacid are: - Treatment of acute uncomplicated urinary tract infections caused by microorganisms sensitive to fosfomycin in adult men, women and girls over the age of 12 years. — Prevention during diagnostic procedures and surgical interventions in adult patients.
Directions for use: Ureacid is taken as a solution for oral administration on an empty stomach, preferably before bedtime after emptying the bladder. The contents of the sachet should be poured into ½ glass of cold water, stir until completely dissolved and drink immediately. The dosage regimen is set individually. Typically, a single dose for adults, including elderly patients in the acute phase of the disease is 3 g (1 sachet) once. In order to prevent urinary tract infection during surgery and transurethral diagnostic studies, take 3 g of fosfomycin (1 sachet) 3:00 before the intervention and 24 hours after the intervention.
Side effects: The most common adverse reactions with a single dose of Ureacid include disorders of the gastrointestinal tract, mainly diarrhea. These phenomena are most often short-lived and go away on their own. In each frequency group, adverse reactions are presented in decreasing order of severity. Infections and infestations: vulvovaginitis. From the immune system: anaphylactic shock, allergic reactions. From the nervous system: headache, dizziness, paresthesia. From the cardiovascular system: tachycardia, arterial hypotension. From the respiratory system, chest and mediastinal organs: asthma. From the digestive system: diarrhea, nausea, digestive disorders, abdominal pain, vomiting, pseudomembranous colitis. From the skin and subcutaneous tissues: rash, urticaria, itching, angioedema. Systemic disorders: fatigue. Contraindications: Contraindications to the use of the drug Ureacid are: hypersensitivity to the components of the drug, severe renal failure (creatinine clearance <10 ml/min), undergoing hemodialysis.
Pregnancy: During pregnancy, the use of the drug Ureacid is possible if necessary, when the expected effect of therapy for the mother exceeds the potential risk to the fetus. According to available data, fosfomycin trometamol has neither teratogenic nor fetotoxic effects. Animal studies also showed no reproductive toxicity. During breastfeeding, use of the drug should be discontinued. No studies have been conducted on use during breastfeeding.
Interaction with other drugs: Concomitant use of Ureacid with metoclopramide and other drugs that increase gastrointestinal motility reduces the absorption of Ureacid, which leads to a decrease in the concentration of Ureacid in serum and urine.
Overdose: Symptoms of an overdose with Ureacid: vestibular disorders, hearing loss, metallic taste in the mouth and a general decrease in taste perception. Treatment: symptomatic and supportive therapy. It is recommended to drink plenty of fluids to increase urine output.
Storage conditions: Store in original packaging at a temperature not exceeding 25 ° C out of the reach of children.
Release form: Ureacid - granules for oral solution. Packaging: 8 g of the drug (3 g of active ingredient) in a sachet; 1 sachet in a cardboard box.
Composition: 1 sachet Ureacid contains fosfomycin trometamol in terms of fosfomycin 3 g. Excipients: sucrose (sucrose), sodium saccharin, tangerine flavor, orange flavor.
Additionally: The use of broad-spectrum antibiotics, including fosfomycin trometamol, can lead to antibiotic-associated colitis (including pseudomembranous colitis). Therefore, the possibility of this diagnosis should be considered in patients who experience severe diarrhea during or after taking fosfomycin trometamol. If the diagnosis is confirmed, appropriate treatment should be started immediately. In this case, drugs that inhibit peristalsis are contraindicated. Concomitant food intake slows down the absorption of fosfomycin. Therefore, it is advisable to use the drug on an empty stomach or 2-3 hours after meals. Ureacid contains sucrose. Patients with diabetes and those who need to follow a diet should take into account that 1 packet of Ureacid contains 2.213 g of sucrose. Ureacid should not be used in patients with fructose intolerance, glucose-galactose malabsorption syndrome or sucrase-isomaltase deficiency. The ability to influence the reaction rate when driving vehicles or other mechanisms. There is no data confirming the effect on reaction speed. It can be used for the treatment of acute uncomplicated lower urinary tract infections in women over 12 years of age. There is insufficient data regarding the use of the drug for therapeutic purposes in children over the age of 12 years, as well as sufficient data regarding the use of the drug for preventive purposes in both boys and girls.
Trial of Monural
Today, Monural is the most powerful antibacterial agent used in the treatment of cystitis and other infectious inflammations of the genitourinary tract. He underwent scientific studies that proved that 90% of strains of genitourinary system infections are highly sensitive to fosfomycin, the main active ingredient. So there are very few situations where monural did not help in the treatment of cystitis.
This drug is prescribed in cases where other drugs have proven ineffective or impossible to use.
Studies were conducted in the USA in which Monural was compared with other antibiotics in the treatment of bladder inflammation in women. The drugs that were compared with fosfomycin were the following: amoxicillin, ofloxacin, pipemidic acid and ceftriaxone.
The subjects were asked to undergo treatment. Antibiotics were taken intermittently as a single dose. The duration of treatment was 3–5 days. The results of the tests showed that when treated with fosfomycin, the infection was destroyed in 90% of cases within 7 days of observation. For other drugs this figure was only 80%.
Monural has proven to be a safe drug. It can be used to treat pregnant women and children.
According to research results, its single dose was as effective as multiple doses of other antibiotics. Thus, one serving of Monural in the treatment of bladder inflammation was equivalent to a seven-day course of Furadonin.
Comparison of safety of Uronormin-fa and Monural
The safety of a drug includes many factors.
At the same time, in Uronormin-fa it is quite similar to Monural. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing the metabolism of Uronormin-pha, as well as Monural, we look at which organ is the metabolizing organ and how critical the effect on it is.
The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Uronormin-fa does not have any risks when used, just like Monural.
Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Uronormin-fa and Monural.
Analogs for the treatment of cystitis
The high cost of Monural (500–800 rubles) is beyond the means of many people. In this case, they should use an analogue of Monural, which is cheaper in cost. Here are several drugs that can easily replace the original in the treatment of bladder inflammation:
Alphacet. The mechanism of action of this antibiotic is almost no different from the mechanism of action of Monural, but you should drink it more often than the original.
Furadonin. This drug has proven itself both in the treatment and prevention of pathologies of the genitourinary system, however, it is not as fast-acting as Monural.
Furagin. This is an antibacterial drug that protects against infection. The advantage of Furagin is that it has a healing effect for 14 days. If it is not possible to purchase monural, analogues for cystitis can help cope with the disease.
Comparison of addiction in Uronormin-fa and Monural
Like safety, addiction also involves many factors that must be considered when evaluating a drug.
So, the totality of the values of such parameters as “syndrome o” in Uronormin-fa is quite similar to the similar values in Monural. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, in Uronormin-fa the meaning of “o syndrome” is quite small, however, the same as in Monural.
