Nitroxoline during early pregnancy: indications and consequences

The topic of an effective remedy for cystitis has been and remains relevant due to the fact that the disease is widespread throughout the world.

It is worth noting that women suffer from inflammation of the bladder many times more often than men. That is why it is women who are mostly looking for an effective remedy for cystitis.

To understand which remedy will help you against cystitis, you should learn more about the nature of the disease. Cystitis is accompanied by difficulty urinating, pain and burning during it, the presence of ichor and blood in the urine, as well as sharp pains in the lower abdomen. As you understand, the symptoms cause a lot of inconvenience, so many are trying to find the best cure for cystitis.

The disease can be triggered by hypovitaminosis, hypothermia and excessive physical exertion. But more often, a bacterial infection pushes us to the need to look for the best cure for cystitis. If you want to recover quickly, you will hardly be able to do without antibiotics for cystitis.

It is worth noting that the drug can curb cystitis only if it is prescribed to you by an experienced doctor. Without its prescription, taking antibiotics for cystitis is only permissible in case of very severe pain.

There are currently a variety of antibiotics on the market that help with cystitis. Therefore, choosing a medicine for cystitis on your own will be quite difficult. What should you look for when looking for a medicinal cystitis drug? To choose suitable medications for cystitis, look at it:

- efficiency;

- safety;

— ease of use;

- price.

Remember that to select the best medicine for cystitis, you should consult a doctor, since the matter is purely individual. Some women believe that without a doctor they will not be able to choose the right medicine to save them from cystitis, so before visiting a specialist they only take painkillers. For example, no-spa, as well as herbal preparations (infusion of lingonberry leaves and berries), help against the pain of cystitis.

Composition and release form

The drug is sold in tablet form. The main active ingredient is nitroxoline. One tablet contains 50 mg of the active ingredient. The product is positioned as an antimicrobial product for systemic use. General category - antibacterial pharmacological substances.

Pharmacological qualities

Nitroxoline is a uroantiseptic of synthetic origin. The mechanism of action is chelation. Influences the pathogen through three effects:

• bacteriostatic;
• bactericidal;
• fungicidal.

The drug is prescribed to combat infections caused by gram-positive, gram-negative bacteria and fungal agents. The maximum degree of effectiveness is achieved in the presence of the following microorganisms in the foci: Escherichia coli, Ureaplasmaurealyticum, Mycoplasmahominis, Candidaspp.

The tablets partially inhibit the pathological activity of Proteus, Corynebacteriumdiphteriae, Enterococcus spp and staphylococci.

The active substance is quickly absorbed. The peak concentration is recorded 2 hours after taking the tablet drug. The antimicrobial component is metabolized in the liver and excreted through the urinary tract with urine (partially with bile).

Indications for use of an antimicrobial agent

Nitroxoline tablets help against urinary tract pathologies. The medicine helps eliminate the source of inflammation and the source of the pathogen. The drug is recommended to be taken for the following diseases:

• infected adenoma;
• pyelonephritis;
• cystitis;
• prostate carcinoma, aggravated by inflammatory or infectious processes;
• urethritis;

• epididymitis.

An antimicrobial agent can completely replace an antibiotic when organizing preventive measures in the postoperative period. This is relevant specifically when performing surgical interventions on the genitourinary organs, in various pathological conditions of the kidneys. The product can be used for a similar purpose after catheterization and during cystoscopy.

Comparison of the safety of Nitroxoline and Palin

The safety of a drug includes many factors.

At the same time, in Nitroxoline it is quite similar to Palin. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing the metabolism of Nitroxoline, as well as Palin, we look at which organ is the metabolizing organ and how critical the effect on it is.

The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Nitroxoline does not have any risks when used, just like Palin.

Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Nitroxoline and Palin.

Instructions for use

It is recommended to take tablets during meals or immediately after meals. Adult men and women need to take 100 mg of the drug 4 times a day.

The pediatrician calculates the dosage for children individually.

Complex urological diseases require increasing the single dose to 200 mg. The frequency of administration per day is 4 times.

How much antimicrobial medication to take is decided solely by the doctor who is treating the patient and developing the dosage. The average duration of the course of therapeutic influence is from 2 to 3 weeks. Treatment with repetition of basic courses several times in a row with a break of 14 days is acceptable.

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Comparison of side effects of Nitroxoline and Palin

Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.

Nitroxoline's side effects are almost the same as Palin's. They both have few side effects. This implies that the frequency of their occurrence is low, that is, the indicator of how many cases of an undesirable effect of treatment are possible and registered is low. The undesirable effect on the body, the strength of influence and the toxic effect of Nitroxoline are similar to Palin: how quickly the body recovers after taking it and whether it recovers at all.

Contraindications for use

The antimicrobial agent cannot be used if you are hypersensitive to this pharmacological product. A list of other contraindications is formed:

• liver pathologies of varying severity;
• conflict with quinoline medicinal products;
• neuritis;
• cataract;

• during pregnancy in any trimester;
• active lactation period;
• deficiency of glucose-6-phosphate dehydrogenase.

Considering the significant list of possible contraindications, only the attending physician can prescribe the drug. He will not only calculate the dose, but also take into account contraindications and compatibility with other drugs.

Comparison of addiction between Nitroxoline and Palin

Like safety, addiction also involves many factors that must be considered when evaluating a drug.

So, the totality of the values ​​of such parameters as “o syndrome” in Nitroxoline is quite similar to the similar values ​​in Palin. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, Nitroxoline has a fairly low value of the “syndrome”, just like Palin.

Side effects

Given the specific mechanism of action of the antimicrobial agent, as well as the duration of therapy, Nitroxoline may cause side effects. The main negative manifestations during antimicrobial therapy:

• anorexia;
• obsessive nausea;

• severe vomiting;
• skin rashes;
• polyneuropathy;
• cephalalgia of varying degrees of intensity;
• disturbances in liver function;
• itching;
• paresthesia;
• peripheral neuritis;
• tachycardia;

• ataxia.

If a whole set of complications develops, the course is interrupted. The doctor, analyzing the situation, makes a decision regarding further tactics for managing the patient.

Rules for drug combinations

To enhance the pharmacological effect, Nitroxoline is combined with tetracycline antibiotics. The summation of effects is also relevant for the treatment of complex mixed infections. Nalidixic acid and hydroxides reduce the pharmacological potential of antimicrobial tablets.

Antacids, as well as pharmacological products containing magnesium, interfere with the absorption of the antimicrobial agent.

Nitrofurans are strictly prohibited from being introduced into a therapeutic regimen if Nitroxoline is already present in it. The reason is an increase in negative neutrotropic influence.

Comparison of the effectiveness of Nitroxoline and Palin

Nitroxoline is more effective than Palin - this means that the ability of the medicinal substance to provide the maximum possible effect is different.
For example, if the therapeutic effect of Nitroxoline is more pronounced, then with Palin it is impossible to achieve this effect even in large doses.

Also, the speed of therapy is an indicator of the speed of the therapeutic action; Nitroxoline and Palin are also different, as is bioavailability - the amount of a medicinal substance reaching the place of its action in the body. The higher the bioavailability, the less it will be lost during absorption and use by the body.

Features of application

Treatment of urological diseases with Nitroxoline tablets should not last more than 4 weeks. The drug contains a specific dye. In some cases, allergic reactions to this particular component of the tablets are possible.

The risk is noted in patients who suffer from atypical sensitivity to acetylsalicylic acid.

The tablets contain lactose. For this reason, the drug is not prescribed to people with the following pathological abnormalities:

• hereditary galactose intolerance;

• glucose-galactose malabsorption syndrome;
• lactase deficiency.

It is worth notifying your doctor in advance if there are problems of this kind. The tablets contain sucrase; patients with diabetes are forced to refuse the medicine. It is not recommended to drink alcohol while taking the drug.

When is Nitroxoline prescribed to pregnant women?

Today, the category of action of the drug on a pregnant child has not been determined, there are no clinical studies, the pharmacokinetics have not been sufficiently studied - this explains the concern whether Nitroxoline can be used during pregnancy. All responsibility for the use of the medicine lies with the doctor.

No negative effects of Nitroxoline components on the fetus were detected

Inflammatory diseases of the urinary organs (cystitis, pyelonephritis) complicate pregnancy. The development of infection provokes the formation of stones. Some doctors decide to prescribe the drug to women in the 2nd and 3rd trimester. No negative effects of Nitroxoline components on the fetus were detected. Most children are born healthy. Doctors do not associate the existing rare deviations from the norm with the use of the drug.

The drug contains no dangerous components. If the benefits of the medicine significantly outweigh the possible harmful effects, the doctor prescribes Nitroxoline to help you recover faster. It is important to strictly follow the recommendations for use, observe the indicated dosages, in order to eliminate the occurrence of unpleasant side effects and give birth to a healthy baby.

Analogs

In antibiotic therapy and antimicrobial treatment, the use of analogues is a common practice. It is also possible to replace Nitroxoline tablets.

Substitutes for the drug are Nixibiol, Niuron, Nitroxoline UBF, 5-Nitrox. They are practically no different from each other. The key distinguishing features are the manufacturers and the cost of the pharmacological product.