Urological diseases involving the lower urinary tract, including recurrent cystitis, pose a serious challenge to the health of people around the world.
Every year in Europe, more than tens of millions of requests for medical help with similar pathologies are registered. In our country, this figure may be higher, since most people prefer to self-medicate and seek help primarily from pharmacists, medical forums, and advice from friends. The question is: Canephron N or Nitroxoline, which is better?
Comparison of the effectiveness of Nitroxoline and Canephron H
The effectiveness of Nitroxoline is quite similar to Canephron H - this means that the ability of the drug substance to provide the maximum possible effect is similar.
For example, if the therapeutic effect of Nitroxoline is more pronounced, then using Canephron H, even in large doses, will not achieve this effect.
Also, the speed of therapy - an indicator of the speed of therapeutic action - is approximately the same for Nitroxoline and Canephron H. And bioavailability, that is, the amount of a drug reaching its site of action in the body, is similar. The higher the bioavailability, the less it will be lost during absorption and use by the body.
Sources
- A.L.Vertkin, G.Yu.Knorring. Recurrent cystitis and modern herbal medicine. Journal Local Therapist. 2017; 05:15
- V.V. Rafalsky, L.V. Khodnevich. Acute cystitis: approaches to the choice of antimicrobial therapy. Journal of Consilium Medicum. 2010; 4: 48-53. Electronic version: https://www.mif-ua.com/archive/article/22691
- A.P. Nikonov. Urinary tract infections in pregnant women (slide presentation). Journal of Gynecology. 2003; 01: 4-9. Electronic version: https://old.consilium-medicum.com/media/gynecology/03_01/36.shtml
- S.V. Yakovlev, I.I. Derevyanko. What antibiotics are really needed to treat urogenital infections? Journal of Consilium Medicum. 2004; 01:40-45. Electronic version: https://www.fesmu.ru/elib/Article.aspx?id=109412
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Comparison of the safety of Nitroxoline and Canephron H
The safety of a drug includes many factors.
At the same time, in Nitroxoline it is quite similar to Canephron H. It is important where the drug is metabolized: medicinal substances are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing the metabolism of Nitroxoline, as well as Canephron H, we look at which organ is the metabolizing organ and how critical the effect on it is.
The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Nitroxoline does not have any risks when used, just like Canephron H.
Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Nitroxoline and Canephron H.
Features of cystitis therapy
If treated incorrectly, such a seemingly simple disease as acute cystitis becomes chronic with frequent exacerbations. If the inflammatory process proceeds without complications, then only the mucous membrane of the urinary canal and bladder is affected. If the infection penetrates higher, the renal pelvis is involved and there is a risk of developing pyelonephritis, chronic renal failure and urosepsis.
There are 2 types of urinary infections: without complications, occurring without disruption of urine drainage and associated serious pathologies, and complicated. In all cases, treatment comes down to three mandatory actions.
- Prescription of an effective antibacterial drug for internal use.
- Drink plenty of fluids to flush out the infectious agent.
- The use of herbal preparations that have a complex effect on the mechanisms of development of urinary tract diseases.
Comparison of addiction between Nitroxoline and Canephron H
Like safety, addiction also involves many factors that must be considered when evaluating a drug.
So, the totality of the values of such parameters as “syndrome o” in Nitroxoline is quite similar to the similar values in Canephron H. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of substances that cause addiction or dependence into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, Nitroxoline has a fairly low “syndrome” value, just like Canephron H.
Nitroxoline: brief description
The drug contains the active ingredient of the same name and is available only in tablets.
The medicine quickly and effectively fights against:
- intestinal bacteria;
- pathogenic fungi Candida;
- protozoa Trichomonas.
One of the advantages of a pharmaceutical product is that pathogenic organisms do not develop immunity to it . Therefore, Nitroxoline can be prescribed to patients without determining the type of microbe.
This also allows the use of Nitroxoline for a long time as a preventive measure against exacerbation of pyelonephritis.
When to take
Nitroxoline effectively fights against:
- pyelonephritis;
- cystitis;
- urethritis;
- epididymitis;
- bacterial infection of prostate adenoma and carcinoma.
Also, doctors often prescribe it to prevent infectious infection after surgery or a diagnostic examination of the patient (cystoscopy, resectoscopy, catheterization).
Contraindications, side effects
The use of the medicine may harm patients who suffer from:
- serious liver diseases;
- impaired renal function;
- pharmaceutical intolerance;
- cataracts;
- neuritis;
- anemia.
Nitroxoline may cause the following side effects:
- tachycardia;
- problems with appetite;
- headache;
- ataxia;
- allergic manifestations.
special instructions
If we compare Nitroxoline with Canephron, the former is not suitable for treating pregnant and lactating women. Corresponding experiments have not been carried out, but experts recommend not to risk it. It is better for women to take a safer analogue of Nitroxoline during this period.
Analogs
If the patient cannot drink Nitroxoline, he may be prescribed effective substitutes:
- 5 NOK;
- Canephron;
- Metronidazole;
- Phytolysin.
Only the attending physician should decide which drug is best to take from the above.
Comparison of side effects of Nitroxoline and Canephron H
Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.
Canephron H has more side effects than Nitroxoline. This implies that the frequency of their occurrence is low in Canephron H and low in Nitroxoline. Frequency of manifestation is an indicator of how many cases of an undesirable effect from treatment are possible and registered. The undesirable effect on the body, the strength of influence and the toxic effect of drugs are different: how quickly the body recovers after taking it and whether it recovers at all. When using Canephron H, the body's ability to recover faster is higher than that of Nitroxoline.
Canephron: brief description
Canephron is considered a good drug with a pronounced diuretic, anti-inflammatory, antiseptic and antispasmodic drug. The drug is widely used for the treatment of urological diseases. The main advantage of Canephron is its combination with many medications .
The drug is available in the form of tablets and solution for oral administration. It is based on extracts of lovage, centaury, rosemary and rose hips.
Indications for use
Canephron fights well with:
- urethritis;
- cystitis;
- pyelonephritis;
- nephritis;
- glomerulonephritis;
- inflammations resulting from injuries;
- pathological processes in MS;
- chronic kidney diseases.
Contraindications, side effects
Canephron is contraindicated for the treatment of patients who:
- do not accept the drug;
- suffer from serious kidney and liver pathologies;
- suffer from peptic ulcers.
Canephron rarely provokes negative effects, however, some patients noted that during treatment they developed:
- nausea, vomiting;
- allergy;
- gastrointestinal disorder.
Typically, these symptoms disappeared within a few days after starting treatment.
Analogs
If the patient cannot take Canephron, the doctor is obliged to select effective substitutes. These are Cyston and Urolesan.
Characteristics of Nitroxoline
The active component of the drug is nitroxoline. Additional components of the drug that perform auxiliary functions are the following chemical compounds:
- sucrose;
- povidone;
- Aerosil;
- magnesium carbonate basic aqueous;
- talc;
- titanium dioxide pigment;
- paraffin;
- beeswax;
- yellow-orange dye.
The main form of release of the drug is coated tablets. The drug has a pronounced antibacterial effect.
The active compound has antibacterial properties and belongs to 8-hydroxyquinoline derivatives. The properties of the active component are due to the ability to selectively inhibit the reproduction of bacterial DNA. Nitroxoline is active against gram-positive and gram-negative bacteria and some types of fungi.
The main indications for prescribing the drug are:
- treatment of infectious and inflammatory pathologies of the genitourinary tract - pyelonephritis, cystitis, urethritis, epididymitis, infected adenoma or prostate carcinoma;
- carrying out the prevention of complications during diagnostic and therapeutic procedures - catheterization or cystoscopy, as well as the prevention of infection in the pre- and postoperative period during surgical intervention on the kidneys and genitourinary tract.
When prescribing the drug, one should take into account the possible presence of contraindications for the use of Nitroxoline in the patient, these may be:
- renal dysfunction accompanied by oligo- or anuria;
- severe liver pathologies;
- deficiency of glucose-6-phosphate dehydrogenase;
- neuritis;
- cataract;
- period of pregnancy and lactation;
- high sensitivity to quinolines.
The main indications for prescribing the drug are infectious and inflammatory pathologies of the genitourinary tract.
As side effects, the patient may experience:
- attacks of nausea;
- urge to vomit;
- decreased or complete loss of appetite;
- disturbances in liver function.
In some cases, allergic reactions may develop in the form of skin rashes and itching.
In rare cases, the development of disorders in the functioning of the nervous system was recorded, which manifested themselves:
- ataxia;
- headache;
- paresthesia;
- polyneuropathy;
- neuritis of the optic nerve.
In case of an overdose, the patient may feel:
- attacks of nausea;
- urge to vomit;
- general weakness.
To get rid of the symptoms of overdose, gastric lavage and enterosorbents are taken, and, if necessary, symptomatic treatment is carried out.
The sale of the drug is carried out according to the prescription of the attending physician. The cost of the medicine is about 60 rubles. The shelf life of the medicine is 6 years.
Characteristics of Canephron
The drug is produced in the form of dragees and solution. Plant raw materials are used in the production of the medicine.
In the composition of the dragee, the active components are dried components:
- centaury herbs;
- rosemary leaves;
- medicinal lovage roots.
Herbal ingredients are contained in powder form.
Additional components in the drug are:
- corn starch;
- silica;
- lactose monohydrate;
- povidone;
- riboflavin;
- calcium carbonate;
- dextrose;
- titanium dioxide;
- talc;
- sucrose;
- shellac;
- corn oil;
- iron oxide red;
- glycolic wax.
The main components of Canephron in the form of a solution are extracts obtained from plant materials used in the production of dragees. Additional compounds are ethyl alcohol and purified water.
The drug is capable of having antispasmodic, diuretic, antimicrobial and anti-inflammatory effects on the body.
The drug can be used both as a primary and an auxiliary agent in the drug therapy of infectious pathologies of the bladder and kidneys, incl. cystitis and pyelonephritis.
The drug can be used to treat chronic diseases of a non-infectious nature, incl. interstitial nephritis and glomerulonephritis.
Canephron can be used to treat chronic diseases of a non-infectious nature, incl. interstitial nephritis and glomerulonephritis.
The use of the drug is contraindicated in the presence of alcohol dependence and hypersensitivity to the components of the pharmacological drug.
Caution when using the medication is required if the patient has pathologies that impair the functioning of the liver.
It is prohibited to prescribe the drug to patients under 6 years of age.
It is prohibited to use the medication in the presence of a peptic ulcer in the acute stage and to relieve swelling caused by renal and heart failure.
It is not recommended to prescribe the medicine to patients with renal failure.
Canephron is a drug that is well tolerated by most patients. If there is hypersensitivity, the patient may develop side effects, manifested by hyperemia, skin itching, rashes and urticaria.
In rare cases, a feeling of nausea and vomiting may occur. If any side effects occur, you should stop taking Canephron and consult a doctor for advice.
In clinical practice, cases of intoxication and overdose with Canephron have not been encountered.
Canephron is sold in pharmacies without a prescription. The shelf life of a medicine depends on its dosage form:
- for dragees – 4 years;
- for solution – 2 years.
The cost of the medication varies from 350 to 420 rubles.
Comparison of drugs
The drugs have different chemical compositions. Nitroxoline is a synthesized pharmacological agent, and plant components are used in the production of Canephron.
Nitroxoline exhibits antibacterial properties, and Canephron is able to have a complex effect on the urinary system, exhibiting antispasmodic, diuretic, antimicrobial and anti-inflammatory properties.
Nitroxoline can be used to treat patients with alcohol dependence. Canephron is prohibited for use in this situation.
Medicines have different pharmacokinetic and pharmacodynamic properties.
