Ciprolet eye drops for welding burns

Composition and release form

The medicinal substance of all forms is ciprofloxacin, which belongs to the class of fluoroquinolones.

Available forms:

Tablets are coated, attached to a blister, packed in a box. The color is white, the inside is slightly yellowish. The shape is biconvex.

Tsiprolet injection solution is in a cardboard pack with a loop for fastening.

Please note that special ear drops and the drug Tsiprolet for instillation into the nose are not available. We will describe below how to use the existing eye product in ENT practice.

A combination drug, Ciprolet A, is also produced. To enhance the therapeutic effect, the antibiotic ciprofloxacin is enhanced with tinidazole. The composition has antibacterial, antiprotozoal and antifungal effects. This drug is used for complicated infections caused by a group of pathogens.

Vasoconstrictor drops

After pain relief, a drug is used that will effectively treat pathological symptoms: relieve swelling, remove redness and inflammation, relieve itching.

These drugs are based on adrenergic agonists that act on the receptors of the vascular walls. They cause the blood vessels to constrict, resulting in relief of the symptoms of the disease.

Vasoconstrictor eye drops are very effective, but they cannot be used for a long time. Otherwise, they will cause the opposite effect.

Eye drops after welding with a vasoconstrictor effect are used for no longer than 5 days. Otherwise, addiction to the drug develops and then the symptoms that needed to be eliminated intensify.

Pharmacological effect

The medicine belongs to the group of fluoroquinolones. They differ from other antibacterial drugs in the absence of natural analogues. These are synthetic substances with broad antibacterial action.

Ciprofloxacin, which forms the basis of the drug Ciprolet, belongs to the second generation of fluoroquinolones and is included in the list of essential medicines approved by WHO.

The action of ciprofloxacin is based on the inhibition of natural processes in the cells of infectious pathogens. The medicine disrupts the synthesis of proteins in microbial cells, destroys DNA structures, which leads to their death. The action of ciprofloxacin is bactericidal. At the same time, the drug equally destroys cells at the stage of division and reproduction, as well as those at rest.

The drug is active against many infectious pathogens:

• gram-positive;
• gram-negative aerobic;
• other gram-negative;
• intracellular.

Some microorganisms show resistance to the action of the drug, and Tsiprolet is not used to suppress them.

The addiction of pathogens to the action of ciprofloxacin develops very slowly and is practically not observed. This ensures the effective destruction of microorganisms that cannot be overcome by other types of antibiotics - aminoglycosides, tetracyclines, beta-lactams, penicillins.

Absorption by the mucous membranes of the digestive tract occurs in a short time, the maximum concentration is achieved within 90-120 minutes. From plasma, dissolved ciprofloxacin passes into tissue structures and accumulates in organs affected by microorganisms. It was revealed that the amount of ciprofloxacin in the sore spot is up to ten times more than that contained in the general bloodstream.

Excreted by the kidneys. In case of kidney pathologies, the withdrawal period increases; when consuming, monitor creatinine clearance.

Antibacterial drops

If you receive a burn as a result of exposure to welding, then most likely inflammation has begun. This means the use of antibiotics will be required. But they must be in shape. Which will allow you to apply them topically, directly to the affected area.

The most famous drops with an antibacterial effect:

1. Tobrex;
2. Oftaquix;
3. Gentamicin;
4. Dexamethasone;
5. Taufon or Taurine.

Method of application: by introducing drops onto the conjunctival sac. The dose of use always depends on the severity of the condition, but the usual dosage is:

• For infections with moderate symptoms, antibacterial eye drops after welding are used in the amount of 1-2 drops with an interval of 4 days;
• For infections with symptoms of high severity, it is recommended to reduce the interval of drug administration - 1-2 drops every hour;
• Antibacterial drops can be used for a course of no more than 2 weeks.

Contraindications for use:

1. Intolerance to components;
2. Infancy (less than 1 year);
3. Severe kidney pathologies;
4. Pregnancy and breastfeeding;
5. Myasthenia;
6. Acoustic neuritis.

Important: long-term use of antibacterial eye medications beyond 2 weeks can lead to fungal or secondary bacterial infection.

• Reaction to light in the form of a spasm;
• lacrimation;
• Burning and itching;
• Development of bleeding of mucous membranes;
• Hallucinations.

Contraindications

The use of all types of the drug Tsiprolet is prohibited:

• up to 18 years of age – the unformed children’s skeleton is exposed to negative effects;
• during pregnancy and lactation;
• recorded cases of reactions to fluoroquinolones;
• allergy to the components of the composition;
• some forms of colitis.

If the need for Tsiprolet therapy is identified, nursing mothers will have to transfer the child to artificial feeding. The withdrawal period is the time of therapy plus another week.

In children, even with a short regimen, there were cases of changes in the structure of the tendons, so bacterial infections of the ENT organs have to be treated in other ways.

The medicine is prescribed with constant monitoring of the condition:

• elderly patients (over 65 years old);
• with severe atherosclerosis;
• with impaired patency of the blood vessels of the brain;
• patients with mental disorders;
• for epilepsy.

Failure of the kidneys and liver, as well as dysfunction of these systems, are reasons to refuse to use this antibiotic.

Important: treatment with Tsiprolet requires the consumption of large volumes of liquid to prevent crystalluria - salt retention in the body.

Indications for use

for adults

Tsiprolet is used in the treatment of the following diseases:

1. Lower respiratory tract infections caused by gram-negative bacteria.
2. Chronic obstructive pulmonary disease.
3. Pneumonia.
4. Urinary tract infections.
5. Bronchopulmonary infections.
6. Pelvic inflammatory diseases, including those caused by Neisseria gonorrhoeae.
7. Infections of the gallbladder and biliary tract
8. Purulent otitis.
9. Infections of the musculoskeletal system.
10. Infections of the gastrointestinal tract, including some dental ones.
11. Urethritis and cervicitis caused by gonococcal infection.

for children

For children, Tsiprolet can be prescribed for the treatment of:

1. Bronchopulmonary infections caused by Pseudomonas aeruginosa.
2. Pulmonary form of anthrax.
3. Complicated urinary tract infections...

For the treatment of other diseases, Tsiprolet can be prescribed only at the discretion of the doctor. According to general recommendations, it is better not to prescribe it until 18 years of age - the age of complete skeletal formation.

for pregnant women and during lactation

Tsiprolet passes into breast milk and is therefore contraindicated during breastfeeding. When taking Tsiprolet during pregnancy, there is a possibility of a negative effect of the drug on the bone and cartilage tissue of the fetus, so it is not prescribed for this category of patients.

Possible side effects

The following negative reactions may occur as a result of taking the drug or intravenous infusions:

• hematopoietic disorders - anemia, thrombocytopenia, leukopenia;
• allergic manifestations - general (shortness of breath, swelling, increased photosensitivity), skin (various types of rashes, dryness, peeling, itching);
• reactions of the nervous system - headache, loss of orientation, depression, sleep disturbances;
• sometimes – convulsions, fainting, tinnitus;

• with liver pathologies – jaundice, increased enzyme activity;
• dyspeptic disorders - pain in the epigastric region, vomiting, stool disorders;
• distortion of hearing and taste;
• blood disorders - increased bilirubin, glucose;
• kidney dysfunction – urinary retention, nephritis, hematuria;
• decreased blood pressure, tachycardia;
• loss of tendon strength, arthritis, myalgia.

Other infections may also develop - candidiasis, colitis. Some patients noted weakness, sweating, and a decrease in general tone. Typically, these signs appeared in the case of a long course of therapy.

Dosage and methods of application

Let's look at the basic rules for taking different types of Tsiprolet.

Pills

This form is effectively used for all types of infections. Correct reception time:

• 60-90 minutes before meals;
• 2 hours after eating.

The tablets are swallowed whole, without chewing or crushing. You need to drink about 200 milliliters of water with the medicine.

For the treatment of ENT organs, the following dosages are used:

1. Mild course - 250 milligrams 2 times a day. 5-7 days.
2. Moderate - 500 milligrams 2 times. 7-10 days.
3. Severe complicated forms - 750 milligrams 2 times. 10-14 days.

One approach is used to treat all pathologies. If the disease was caught at the initial stage, a minimum amount (250 milligrams) of medication is used and a shortened course of 3-7 days.

With an average infection and complexity of the disease, the amount of Tsiprolet is increased to 500 milligrams, and the treatment time is 7-10 days.

In case of severe infection, significant infectious damage to any organs, a dosage of 750 milligrams is required. The duration of therapy increases significantly and averages 14 days, reaching 21-28 in some cases.

The medicine Tsiprolet is used twice – in the morning and evening.

Instructions for use require monitoring creatinine levels in patients with kidney problems. When clearance is below 20 milliliters per minute, it is proposed to use a volume of product reduced by 2 times relative to the recommended one.

Solution for drip infusions

The medicine is used for intravenous infusions. The drug Tsiprolet is administered by drip using one of the following schemes:

• 200 milligrams of Tsiprolet – in 30 minutes;
• 400 milligrams - in 60 minutes.

Infusions are performed twice a day, maintaining an interval of 12 hours. For infections affecting the ENT organs, a dosage of 200 milligrams is usually chosen. For complicated types of all diseases, the dose is raised to 400 milligrams. The duration of therapy is determined based on the severity of the course and generally lasts 7-14 days.

If there is no obvious improvement, the course of taking Tsiprolet is extended for a week or the drug is changed to another antibiotic.

After a few days, intravenous infusions are replaced with treatment in tablet form.

Eye drops

At the beginning of treatment, more frequent administration of drops is used, then the frequency of use of the medicine is reduced:

• for uncomplicated course – 1-2 drops every 4 hours;
• for severe cases - 2 drops every 60 minutes.

For bacterial ulcerations of the cornea, it is recommended to drip Tsiprolet into the eye every 15 minutes for 6 hours, then after 30 minutes. The next day, drops are applied every hour, consistently reducing the number of instillations daily and bringing it to 4 per day. If the cornea has not recovered, the course may be extended.

In ENT practice, this type of Tsiprolet is sometimes used for the treatment of otitis media, as an external remedy. Eye medicine is dropped into the ear canals to remove pathogens.

Indications:

• otitis media and external;
• after operations on the ear canal, to prevent infection.

Before use, a flora sensitivity test is performed.

Instillations are performed 4 times a day, 1-2 drops of Tsiprolet in each passage. Treatment lasts 7-10 days, after completion an additional analysis is carried out to determine the need for extension.

Please note that only an otolaryngologist can give permission to instill eye drops into the ear. The drug Tsiprolet cannot be used on its own.

To accurately determine the duration of treatment, bacteriological studies are carried out to identify the quantitative characteristics of infection. After stopping the infection, Tsiprolet is used for another 3 days so that the disease does not return.

How to increase the effectiveness and reduce negative reactions from taking Tsiprolet:

• Before starting the course, it is useful to take an antibiotic sensitivity test.
• It is necessary to take the tablets at the same time in order to maintain an effective constant amount of the drug and not weaken its content in the tissues and blood. The interval between uses of any form of medication should be the same. With the recommended two-time dosage of the drug - morning and evening.

• The required duration of therapy for any type of disease is determined individually for each person - usually 5-14 days. Even with obvious improvement, you should not stop taking it. The relief may be temporary; you will have to start a new full course of another antibacterial drug again.
• It is necessary to increase fluid intake during treatment to the recommended norm (1.5-2 liters).
• You need to take probiotics to reduce the effect of Tsiprolet on the digestive tract. Usually this is Baktistatin, Linex, Acipol.
• You can only take the medicine with water. This rule should not be broken.
• To reduce the load on the gastrointestinal tract, you should not indulge in heavy and fatty foods while taking Tsiprolet.

It is necessary to strictly observe the dosage of the drug, without reducing or exceeding it.

Drug groups

Therapeutic measures for all types of burns are quite similar, only the doses and duration of the therapeutic course differ depending on the degree of damage to the eye structures.

The main groups of drugs that are used for burn injuries to the eye are shown in the table.

What are the dangers of overdose?

If the dose of Tsiprolet is exceeded, dyspeptic disorders, loss of orientation, and prolongation of the QT interval are possible. Changes in the mucous membranes may appear.

If less than 2 hours have passed since taking the tablets, you need to drink a lot of water and induce vomiting to rinse the stomach. You need to drink more fluids to flush out the antibiotic from the body. You should also drink a sorbent (for example, activated carbon).

Antidotes and hemodialysis are not used to remove Tsiprolet.

Compatibility with other medications

Laboratory studies and experience with the drug have revealed the following drug interactions:

1. Drugs that prolong the QT interval. Antidepressants, some antiarrhythmics, neuroleptics. The interval may be extended.
2. Reduced effectiveness and absorption of Tsiprolet when used with Didanosine.
3. Interacts with NSAIDs, increasing the risk of side effects.
4. Strengthens the effect of hypoglycemic agents, Cyclosporine, indirect anticoagulants.
5. Increases the concentration in the blood of drugs containing theophylline, tizanidine, clozapine.
6. The penetration of Tsiprolet through the mucous membranes of the gastrointestinal tract worsens when taking antacids, magnesium, potassium, and iron preparations.

The medicine is used in the complex treatment of complex infections together with the following antibiotics: Metronidazole, Clindamycin, Azlocillin, Ceftazidime, isoxazolylpenicillins. Combined use makes it possible to suppress infection by several pathogens, in which Tsiprolet alone is not enough.

Important: in order not to increase the toxic effect of the drugs you are taking and not to reduce their effectiveness, when prescribing, you should tell your doctor about the therapy being carried out.

What are the analogues of the drug?

The following drugs, considered analogues of the drug Tsiprolet, contain the same active ingredient:

• Betaciprol, Russia;
• Vero-Ciprofloxacin, Russia;
• Quintor, India;
• Nircip, India;
• Tsiprinol, Slovenia;
• Ciprodox, India;
• Ciprobay, Germany, Italy;
• Ciproflokasin, Russia;
• Tsifran, India;
• Tsiproxil, Russia.

If you are allergic to the active substance of Tsiprolet, patients are prescribed a medicine with a different active ingredient.

Most otolaryngologists respond positively to the drug Tsiprolet. It is capable, when used correctly, of suppressing the action of an infectious pathogen and quickly helping the patient. Tsiprolet, like all fluoroquinolones, is not addictive to pathogens, this makes its action especially effective and fast.

The drug in all forms is taken exclusively for its intended purpose, carefully following the prescribed treatment regimen. With timely initiation of Tsiprolet therapy, it is possible to avoid negative reactions and complications of the disease.

Pharmacological properties

Pharmacokinetics

Rapidly absorbed from the gastrointestinal tract. Bioavailability after oral administration is 70%. Food intake has little effect on the absorption of ciprofloxacin. The plasma concentration profile of ciprofloxacin after oral administration is similar to that for intravenous administration, so the oral and intravenous routes of administration can be considered interchangeable.

Communication with plasma proteins is 20 - 40%. The average half-life of ciprofloxacin is 6 to 8 hours after a single or multiple dose. Ciprofloxacin penetrates well into organs and tissues: lungs, bronchial mucosa and sputum; organs of the genitourinary system, including the prostate gland; bone tissue, cerebrospinal fluid, polymorphonuclear leukocytes, alveolar macrophages. Excreted primarily in urine and bile.

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Pharmacodynamics

Tsiprolet® is a broad-spectrum antibiotic from the group of fluoroquinolones. Suppresses bacterial DNA gyrase (topoimerases II and IV, responsible for the process of supercoiling of chromosomal DNA around nuclear RNA, which is necessary for reading genetic information), disrupts DNA synthesis, growth and division of bacteria; causes pronounced morphological changes (including cell wall and membranes) and rapid death of the bacterial cell.

https://www.youtube.com/watch?v=sCTAfLW8p54

It acts bacteriostatically on gram-negative microorganisms during the dormant period and bactericidally during the division period (since it affects not only DNA gyrase, but also causes lysis of the cell wall), on gram-positive microorganisms it is bactericidal only during the division period. Low toxicity for the cells of the macroorganism is explained by the absence of DNA gyrase in them. Tsiprolet® is active against most strains of microorganisms invitro and invivo:

— aerobic gram-positive microorganisms: Corynebacterium diphtheriae, Enterococcus faecalis, Listeria monocytogenes, Staphylococcus spp., including Staphylococcus aureus, epidermidis, Streptococcus pyogenes, agalactiae, pneumoniae, Streptococcus (groups C, G), Viridans group streptococci;

— aerobic gram-negative microorganisms: Acinetobacter spp., including Acinetobacter anitratus, baumannii, calcoaceticus, Actinobacillus actinomycetemcomitans, Bordetella pertussis, Citrobacter freundii, diversus, Enterobacter spp., including Enterobacter aerogenes, agglomerans, cloacae, sakazakii, Escherichia coli, Gardnerella vaginalis, Ha emophilus ducreyi , influenzae, Haemophilus parainfluenzae, Helicobacter pylori, Klebsiella spp.

, including Klebsiella oxytoca, pneumoniae, Moraxella catarrhalis, Morganella morganii, Neisseria gonorrhoeae, Neisseria meningitides, including Pasteurella canis, dagmatis, multocida, Proteus mirabilis, vulgaris, Providencia spp., including Pseudomonas aeruginoza, fluorescens, Salmonella spp., Serratia spp., including Serratia marcescens;

— anaerobic microorganisms: Bifidobacterium spp., Clostridium perfringens, Fusobacterium spp., Peptostreptococcus, Propionibacterium spp., Veillonella spp.;

— intracellular microorganisms: Streptococcus pneumoniae, Enterococcus faecalis, Chlamydia pneumoniae, psittaci, trachomatis, Legionella spp., including Legionella pneumophila, Mycobacterium spp., including Mycobacterium leprae, tuberculosis, Mycoplasma pneumoniae; Rickettsia spp.,

Ureaplasma urealyticum, Clostridium difficile, Nocardia asteroids, Bacteroides fragilis, Pseudomonas cepatica, Pseudomonas maltophilia, Treponema pallidum are resistant to the drug Tsiprolet®