Composition and release form
Tapticom is a colorless liquid without visible sediment, which has no distinct odor. The drug is available in unit doses of 0.3 ml, which are packaged in foil wrapping and placed in a cardboard box. Each tube is designed for one instillation in both eyes.
Active ingredients:
- tafluprost – 15 mcg;
- timolol – 6.84 mcg.
Glycerol, polysorbate, sodium hydrogen phosphate and disodium edetate are used as auxiliary components.
Description of the drug
Tapticom dropper tubes are packaged in foil bags (ten pieces each), which are then placed in cardboard boxes. One box contains three bags of dropper tubes. The shelf life of an unopened package of Tapticom eye drops is three years. An open foil package can be stored for no longer than twenty-eight days at a temperature not exceeding 25 ° in a place protected from light.
Care must be taken to ensure that the packaging of the medicinal product is kept out of the reach of children. Tapticom eye drops are a combined ophthalmic drug that includes two active ingredients: tafluprost, timolol. One milliliter of the drug contains 0.015 mg of tafluprost and 5 mg of timolol. The drops also contain excipients: water for injection, sodium hydroxide, glycerin sodium phosphate, Trilon B, polysorbate 80, dodecahydrate, concentrated hydrochloric acid. When treating ophthalmic diseases, drops are used once a day, one drop at a time. The drug is instilled into the conjunctival sac of the affected eye(s).
The dose should not exceed one drop. In cases where treatment is interrupted, the eye should be instilled with the next dose without increasing it.
No dosage changes of Tapticom are required in elderly patients.
Indications for use
Most often, Taptic eye drops are prescribed for the treatment of open-angle glaucoma or ocular hypertension. The medicine is also prescribed to people with individual intolerance to ophthalmic products that contain preservatives. Tapticom is often prescribed for combination therapy when the patient’s body does not respond sufficiently to the use of local beta-blockers and prostaglandin analogues.
Nozdrin: properties
Microorganisms Bacillus amyloliquefacien, which are part of the drug, multiply, secrete specific enzymes and antibiotics, which determines its following properties: - Nozdrin has a fairly high antagonistic activity against opportunistic and pathogenic organisms that seek to enter our body through the respiratory system; — Nozdrin has good regenerative properties in relation to the nasal mucosa; — Nozdrin has proteolytic, anti-inflammatory and antiseptic properties.
Restrictions on use
Since Tapticom eye drops have a pronounced pharmacological effect, they have restrictions on their use. Before using the drug, the patient in any case must carefully read the instructions and become familiar with the contraindications. You should stop using drops for the following pathologies:
- individual intolerance to active ingredients;
- bronchial asthma;
- temporary problems with respiratory function;
- presence of severe pulmonary diseases;
- heart failure;
- sinus bradycardia;
- recent cardiogenic shock.
Patients with kidney or liver diseases should use the drug with extreme caution. If side effects occur in these organs while using the medication, you must immediately stop therapy.
Indications and contraindications for use
Indications for the use of Taptic eye drops are the need to reduce intraocular pressure in patients diagnosed with open-angle glaucoma or ocular hypertension. The drug is prescribed in cases where it is necessary to use medications that do not contain preservatives. Tapticom eye drops are also prescribed to patients who require combination therapy because they do not respond sufficiently to local therapy with beta-blockers or prostaglandin analogues.
Contraindications for the use of Taptic eye drops are:
- The presence of an allergic reaction to any of the active ingredients or auxiliary components of the drug;
- Existing respiratory irritation;
- Bronchial asthma (including a history);
- Chronic obstructive pulmonary disease in severe form;
- Sinus bradycardia, sick sinus syndrome, as well as sinoatrial block, II-III degree block, which is not controlled by a pacemaker;
- Presence of severe heart failure;
- Cardiogenic shock.
The use of Taptic eye drops in patients with diagnosed renal or liver failure has not yet been sufficiently studied. It is important to use the drug with caution in this group of patients.
Tapticom drops are used only as prescribed by a doctor.
During pregnancy
The drug is used with caution at any stage of pregnancy. This comes with the risk of dangerous side effects. This is only possible when the desired benefit outweighs the possible harm.
Tapticom drops can be used during breastfeeding.
For small children
Tapticom eye drops are not used in pediatrics. This is a drug for the treatment of ophthalmic diseases in adult patients.
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Recommendations for use
You can start therapy only after the medication has been prescribed by a doctor, who will also determine the dosage and duration of use. According to the accompanying instructions, when instilled, the drops should be at room temperature, so it is recommended to hold them in your hands for several minutes before use. Next, you need to throw your head back, move the lower eyelid and carefully drip the solution into the conjunctival sac from a dropper tube. It is important to ensure that the solution is evenly distributed throughout the eyeball. After instilling the drug, it is recommended to lie down with your eyes closed for 15–20 minutes.
How often instillation will be required depends on the type and stage of the disease, as well as the condition of the patient. In most cases, the product is instilled no more than once a day.
Instillation must be carried out very carefully, trying to prevent the solution from getting on the skin around the eyes. This is due to the fact that the medicine can cause darkening of the skin.
Possible side effects
Doctors strongly advise against using Tapticom eye drops without a prescription, since their improper use can lead to multiple complications. That is why, before prescribing a medicine, a comprehensive diagnosis and study of the patient’s medical record is carried out. But even in such cases, the following manifestations cannot be ruled out:
- temporary difficulty breathing;
- darkening of the epidermis on the eyelids;
- rapid growth and increase in thickness of eyelashes;
- change in pupil shade;
- anaphylactic shock.
Experts do not recommend using the product during simultaneous therapy with beta blockers, as this can lead to excessive dryness of the eye mucosa.
Features of good stagnation
Reaction from the side of the cardiovascular and vascular systems
Like other ophthalmic medications, timolol is absorbed systemically. Since timolol is a beta blocker, it is possible to develop adverse reactions in the cardiovascular and respiratory systems, which occur with systemic stagnation of such drugs. The frequency of systemic adverse reactions after local administration of ophthalmic drugs is lower than with systemic administration. Due to decreased systemic absorption of the drug. section “Method of preparation and dosage”.
Damage to the side of the cardiac system
Patients with cardiac disease (for example, ischemic heart disease, vasospathic angina/Prinzmetal angina and heart failure) and arterial hypotension should be treated with beta blockers seriously Appreciate and look at the celebration of other active speeches. It is necessary to monitor the number of patients with cardiovascular disease before signs of worsening of these diseases and adverse reactions appear.
Through a negative influx for the hour of the pulse, beta blockers should be prescribed with caution to patients with stage I heart block.
Damage to the side of the vessel system
Patients with severe peripheral/circulatory disorders (either severe forms of Raynaud's disease or Raynaud's syndrome) should be treated with caution.
Damage to the side of the respiratory system
It was reported about the development of side reactions on the side of the dichotomy system, incl. lethal, due to bronchospasm, in patients with asthma after administration of certain ophthalmic beta-blockers.
It is important to take care of patients with mild/moderate chronic obstructive diseases of the lungs and only in cases where the crust is exposed to the potential risk.
Impaired liver function
No drug treatment has been established for patients with impaired liver function, so precautions should be taken in such patients.
Immunological reactions and hypersensitivity reactions
Like other ophthalmic drugs, this drug can be absorbed systemically. Dorzolamide, as a sulfonamide, contains a sulfonamide group. Tom Victory reacts, pushing with a systemic stained sulfonamin drug, can be vininka at a mix -free, turn on the cerebral reaction, yak Syndrome of stIvens -Johnson that toxic Epistemic Necroliz. If signs of serious reactions or hypersensitivity reactions appear, stop taking the drug.
When this medicinal product was taken, local side reactions were avoided in the side organs of the eye, similar to the reactions that occur with stagnant eye drops from dorzolamide hydrochloride. If such reactions occur, take a look at the diet about the use of your medication.
When taking beta blockers, patients with atopy or severe anaphylactic reactions to a history of numerous allergies may be more sensitive to the re-influx of such allergens in cases of anaphylactic reactions and may not respond to I take a bath with a heavy dose of adrenaline.
Concomitant therapy
Intra-ocular or external infusion of systemic beta-blockers may be used in patients on timolol who are already weaning off a systemic beta-blocker. Care should be taken to ensure compliance with treatment in such patients. The use of two local beta-blockers is not recommended (section
“Interactions with other medicinal agents and other types of interactions”).
Ingestion of dorzolamide and oral carbonic anhydrase inhibitors is not recommended.
Pripinennya likuvannya
As with systemic administration of beta-blockers, ophthalmic timolol should be administered step by step if there is a need to replace the drug in patients with ischemic heart disease (ICH).
Additional effects of beta blockers
Hypoglycemia/diabetes
Beta blockers should be used with caution in patients susceptible to spontaneous hypoglycemia or in patients with mild diabetes, as beta blockers may mask symptoms of hypoglycemia.
Beta blockers may also mask the signs of hyperthyroidism. The use of beta blockers may lead to a decrease in symptoms.
Illness of the cornea
Ophthalmic beta blockers may cause dry eyes. Patients with corneal diseases should be treated with care.
Anesthesia for surgical procedures
Ophthalmic beta blockers may block the systemic influx of beta agonists, such as epinephrine. The anesthesiologist must be informed that the patient is taking timolol.
Treatment with beta blockers may worsen symptoms in myasthenia gravis.
Additional effects of carbonic anhydrase inhibition
Treatment with oral carbonic anhydrase inhibitors is associated with the development of urolithiasis as a result of disruption of the acid-base balance, especially in patients with a history of sepsis. Although the disruption of the acid-base balance during treatment was not prevented, the development of urolithiasis was rarely reported. Carbonic anhydrase inhibitor fragments when administered locally are absorbed systemically; patients with a history of sebaceous illness may be at greater risk for the development of urolithiasis when administered with Rozacom.
Other features
Treatment of patients with acute glaucoma requires the use of other therapeutic agents in addition to drugs that reduce eye pressure. There was no evidence of this drug benefit for patients with acute closed-cuta glaucoma.
When administered with dorzolamide, corneal swelling and permanent corneal decompensation were reported in patients with existing chronic corneal problems and/or a history of internal surgery. There is a high risk of corneal swelling in patients with a small number of endothelial cells. Follow-up after administration of the drug Rozacom to such patients.
The removal of the lining of the eye was reported after filtration procedures involving the use of aqueous suppressants (for example, timolol, acetazolamide).
As with other antiglaucoma medications, decreased sensitivity to ophthalmic timolol maleate was reported after treatment in some patients. Prote in clinical studies, during which 164 patients were under medical supervision for more than three years, there was no significant difference in the average indicator of internal ocular pressure. For wheel stabilization of the vice.
Vikoristannya contact lenses
It is best to use a preservative – benzalkonium chloride, which may cause irritation to the eyes. Please remove contact lenses before instilling the drug and apply at least 15 minutes before applying them again. It appears that benzalkonium chloride can irritate soft contact lenses.
Suspension during pregnancy or breastfeeding.
Vaginism.
The drug does not stagnate during pregnancy.
It is unknown whether dorzolamide is excreted in breast milk. Timolol is secreted into breast milk, so during the bathing period you should wash your breasts.
This is due to the fluidity of the reaction during treatment with vehicles or other mechanisms.
No studies have been carried out on the delivery of the drug to the presence of ceruvate by transport or through other mechanisms. Possible adverse reactions, such as blurred vision, may negatively affect the ability of some patients to travel by motor vehicle or use other mechanisms.
Interaction with other drugs
So far, no clinical studies have been conducted on the interaction of the drug with other medications. When Tapticom is used simultaneously with ophthalmic agents containing beta-blockers, there is an increased likelihood of a decrease in blood pressure or symptoms of bradycardia. There is also a risk of developing such side effects when using antiarrhythmic drugs, cardiac glycosides and slow calcium channel blockers. With the simultaneous use of ophthalmic drugs containing adrenaline, there is an increased likelihood of temporary dilation of the pupil.
