pharmachologic effect
The drug contains valerian, hops, mint, this composition determines the effect of the drug on the human body. The natural substances that evening valerian contains have a tranquilizing, sedative effect on the body.
The drug also regulates the activity of the heart, has a moderate hypotensive effect, and a mild antispasmodic effect.
Valerian officinalis has a calming effect, reducing stimulation of the nervous system and regulating the activity of the heart. Under the influence of valerian, there is an improvement in the functioning of the gastrointestinal tract, the severity of spasms of the esophagus decreases, and bile is excreted. Valerian helps overcome sleep problems, in particular insomnia .
Under the influence of mint , strength is restored, nervousness and strong agitation that arise due to lack of sleep are eliminated. Mint activates the protective functions of the epidermis and improves the color of the skin.
Mint produces an antiseptic, choleretic, anti-inflammatory, antispasmodic effect, reduces the degree of fermentation in the intestines, and acts as a general tonic. Mint normalizes blood circulation in the brain and improves the condition of cramps in the stomach.
Hops contain essential oil and a number of other components, which together have a diuretic, sedative, antispasmodic, anti-inflammatory, and analgesic effect on the body.
Hop preparations improve the condition of nervous excitability, neurasthenia, and insomnia. Hops preparations are indicated for neuralgia , neuroses , headaches , etc.
Heartbeat is under control
The combination of valerian and motherwort in Evening Plus has a beneficial effect on the condition of not only the nervous system, but also the cardiovascular system.
It is not for nothing that motherwort received the specific name heartwort. In cardiology, plant-based drugs are used for the prevention and treatment of tachycardia, arterial hypertension and some other disorders of the blood vessels and heart.
The effect of motherwort on the cardiovascular system was most actively studied during the Great Patriotic War in conditions of shortage of medicines. This work was carried out by specialists from the Tomsk Medical Institute N.V. Vershinin and D.D. Yablokov. It was possible to establish that the plant is able to slow down the rhythm of heart contractions, increase their strength, expand the coronary arteries of the myocardium, eliminate vasospasm (narrowing of blood vessels caused by contraction of the muscle fibers of their walls), and reduce blood pressure [15]. Scientists name the main substances in motherwort that affect the cardiovascular system:
- saponins have a hypotensive effect, normalize the rhythm of contractions of the heart muscle, and increase the strength of these contractions;
- triterpenes have an antiatherosclerotic effect (M.Y. Bilozir, V.P. Novikov, 2008 [16])
- the alkaloid stachydrine slows down the heart rate and lowers blood pressure;
- iridoids (augol, ayugoside, galiridoside) dilate the vessels that feed the heart muscle, reduce blood pressure, normalize heart rhythm, and increase the force of myocardial contractions;
- potassium and sodium salts regulate blood pressure on the walls of blood vessels;
- calcium salts are necessary for the contraction of myocardial muscle fibers and regulate the rhythm of these contractions;
- flavonoids (rutin, derivatives of quercetin and apigenin) strengthen blood vessels, eliminate their spasms, reduce blood pressure, and slow down the heart rate;
- Lavandulifolioside reduces heart rate, lowers blood pressure, lengthens the time it takes for excitation to pass from the atria to the ventricular myocardium, the time during which electrical excitation of the myocardium provides contraction of the ventricles, and the time of excitation of the ventricles of the heart (K. Milkowska-Leyck, B. Filipek, H. Strzelecka , 2002 [17]);
- cardiac glycosides of the bufadienolide type delay the heart rhythm in the stage of short-term myocardial rest and enhance its contraction, thereby eliminating arrhythmia and normalizing the work of the heart muscle (A. Ya. Kobzar, 1990 [18]]; A. Matkowski, M. Piotrowska, 2006 [19]);
- leonurine is a natural cardioprotector, effectively reduces vascular muscle tone (CX Chen, CY Kwan, 2001 [20]), has a hypotensive effect, and has pronounced anti-inflammatory properties (X. Song, T. Wang, Z. Zhang et al., 2015 [21]), reduces the size of the zone of tissue necrosis during a heart attack.
All these substances affect the excitability, automaticity and conductivity of the heart muscle both at the organ level and at the level of the individual cell. In this case, various mechanisms are involved.
In general, motherwort has:
- cardiotonic properties (A.D. Turova, E.N. Sapozhnikova, 1984 [22]; A. Matkowski, M. Piotrowska, 2006 [19]), especially pronounced in neuroses, angina pectoris, arterial hypertension;
- cardioprotective properties (J. Bernatoniene, DM Kopustinskiene et al., 2014 [23]).
- Wojtyniak, M. Szymanski and colleagues (2013) note that the use of motherwort can prevent the development of strokes in patients with hypertension [24]. And IE Orhan, A. Gokbulut (2017) report the possibility of using the plant for heart failure [25].
Valerian officinalis also has a positive effect on the cardiovascular system. The plant improves the functioning of the myocardium in ensuring blood circulation and its saturation with oxygen, dilates the vessels that feed the heart muscle, slows down the rhythm of the heartbeat, and lowers blood pressure.
The authoritative reference book of medicines VIDAL reports that valerian affects heart function both directly and indirectly. In the first case, the plant affects the contractility of the myocardium, its conducting muscle fibers, as well as the tone of the coronary vessels. In the second - on the central nervous system. The fact is that overexcitation of the latter (for example, in a stressful situation) entails narrowing of blood vessels, hardening and thinning of their walls, poor circulation, increased heart rate and, ultimately, weakening of the heart muscle. By exerting an inhibitory effect on the central nervous system, valerian prevents all these processes or eliminates them if they are already taking place.
Let's name the biologically active substances of the plant that support the healthy state of the heart and blood vessels:
- valepotriates relieve spasms of the smooth muscles of the walls of blood vessels, and the antispasmodic effect is 1.6 times greater than papaverine;
- alkaloids and glycosides have a beneficial effect on the functioning of the neuromuscular apparatus of the heart, have a vasodilator and hypotensive effect;
- borneol prevents spasm of blood vessels supplying the heart, and thereby improves blood circulation in them;
- valerenic acid relaxes the striated muscle of the heart and relieves spasm of the smooth muscles of the vascular walls (KJ Kemper, 1999 [2]; H. Hendriks 1985 [26]); the antispasmodic effect is 3 times greater than papaverine (P. Yu. Shkrobotko , A.V. Tkachev, M.S. Yusubov et al., 2009 [27]);
- saponins normalize the conduction activity of the heart muscle, restore heart contraction rhythms, and have a cardioprotective effect;
- Valeric and isovaleric acids relieve spasms of smooth muscles and eliminate heart pain.
antiarrhythmic properties in valerian officinalis in 2009 [28]. And experts from the University of Surrey in the UK found that the plant can prevent increased blood pressure and increased heart rate during stressful situations [29].
Price, where to buy
The price of Evening dragees is 70-80 rubles per pack of 100 pieces.
- Online pharmacies in RussiaRussia
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Evening dragee 60 pcs Biocor
64 RUR order - Evening dragee 120pcs Biocor
118 RUR order
- Evening + motherwort tablets 60 pcs Biocor
102 RUR order
- Tea drink evening calmness biocore 20 bagsBiocor
119 RUR order
- Evening calm tea drink biocore 50 gBiocore
102 RUR order
Pharmacy Dialogue
- Evening dragee (other 200 mg No. 120 (valerian + hops + mint)) Parafarm LLC
73 rub. order
- Evening dragee (other 200 mg No. 50 (valerium + hops + mint)) Parapharm LLC
38 rub. order
- Evening Plus dragee (other 200 mg No. 100 (valerian + motherwort)) Parafarm LLC
110 rub. order
- Evening Plus dragee (other 200 mg No. 50 (valerian + motherwort)) Parapharm LLC
61 rub. order
- Evening Plus dragee 180 mg No. 60Biocor LLC
86 rub. order
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Best before date
24 months
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The description of vitamin Dragee “Evening” is intended for informational purposes only. Before starting to use any drug, it is recommended to consult a doctor and read the instructions for use. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the project does not replace consultation with a specialist and cannot be a guarantee of the positive effect of the drug you use. The opinions of EUROLAB portal users may not coincide with the opinions of the site Administration.
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How to use pills correctly?
When using the product, you must adhere to the recommendations, despite the fact that it contains natural ingredients: valerian, hops, mint. “Evening” according to the instructions is used three times a day, 1-2 tablets with meals. This scheme does not put a serious burden on the organs of the gastrointestinal tract. Typically, the course of therapy is four weeks. Before using the product, it is recommended to consult a doctor who can select the appropriate dosage depending on the individual characteristics of the body.
