Urodan - instructions for use, doses, indications

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Published: 10/01/2020

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• Release form and composition Composition of the medicament

Release form and composition

The release form of Urodan is granules (in plastic jars of 100 g).

1000 mg of granules contain the following biologically active substances:

• methenamine – 3 mg;
• piperazine – 25 mg;
• bearberry (in the form of leaf extract) – 26 mg.

Auxiliary components: sugar – 19 mg, tartaric acid – 356 mg, disodium phosphate – 375 mg.

Composition of the drug

The active substances contained in the drug are the following:

• bearberry leaf extract;
• piperazine;
• urotropin.

The additional components are disodium phosphate and tartaric acid.

Component Properties

Bearberry leaves, which are part of Urodan in the form of a dry, highly concentrated standardized extract, are among the natural antiseptics, due to which the dietary supplement has an anti-inflammatory, diuretic and disinfectant effect.

Cleansing the urinary tract from bacterial flora and inflammatory products is due to arbutin and tannins contained in Urodane.

The antimicrobial properties of the dietary supplement are associated with the glycoside arbutin, which breaks down into free hydroquinone and glucose.

The antiseptic properties of Urodan are determined by the local irritant and antimicrobial effect of hydroquinone. When it is excreted through the kidneys, irritation of the kidney tissue is observed, and increased urination also occurs. Thanks to hydroquinone, the activity of redox reactions increases. It has a significant effect on the following processes: metabolism, oxygen absorption by tissues, blood levels of potassium, glucose, glutathione, reduction of diabetic ketoacidosis.

The therapeutic effect of Urodan is enhanced by the specific action of hydrolysis products and tannins. In low concentrations, tannins block the growth of most microorganisms; in high concentrations, they act as antibacterial agents, which leads to the death of microbes.

Pharmacodynamics

A drug. containing a combination of active substances. When piperazine salts and Li+ with uric acid , easily soluble salts are formed, which are excreted in the urine. At the same time, the urine becomes alkalized.

The extract of bearberry leaves contains the glycoside arbutin , which, under the enzymatic action of arbutase , breaks down into glucose and hydroquinone . Hydroquinone enhances redox processes, has an irritating effect, affects metabolism and oxygen saturation of tissues, normalizes the concentration of glucose , potassium and glutathione , and also reduces the level of ketoacidosis in diabetes . The drug contains tannins that affect the pathogenic flora of the urinary tract and helps cleanse the products of inflammation.

Pharmacokinetics

piperazine and lithium salts, uric acid is transformed into easily soluble compounds and excreted through the kidneys.

What is Trimetazidine?

Belongs to the group of antihypoxic drugs. It has a direct effect on neurons and cardiomyocytes of the brain, helping to optimize their functionality and metabolism. It has a cytoprotective effect, which leads to activation of oxidative decarboxylation. Oxygen absorption is also rationalized (glycolysis is enhanced, the oxidation of fatty acids is blocked).

The medicine allows:

• maintain optimal myocardial contraction frequency;
• monitor phosphocreatinine levels;
• normalize the activity of cell membrane channels;
• prevent excessive accumulation of Na and Ca ions in cardiomyocytes;
• maintain the level of adenosine triphosphoric acid inside cells;
• reduce acidosis and phosphate levels inside brain cells caused by reperfusion and myocardial ischemia;
• neutralize the negative effects of free radicals;
• maintain the condition of cell membranes;
• stop the activation of neutrophils;
• increase the duration of electrical potentials;
• reduce the frequency of angina attacks;
• reduce the need to take nitrates;
• increase endurance during physical activity;
• prevent blood pressure surges.

After taking Trimetazidine, it is absorbed in the gastrointestinal tract in a short time and almost completely; after 2 hours the highest concentration in the blood is reached.

Compound

The drug is produced on the basis of trimetazidine dihydrochloride. The tablets are coated with a white film coating. The composition contains as additional substances:

• calcium stearate;
• polysorbate;
• hyprolose;
• lactose;
• potato starch;
• titanium dioxide;
• talc.

Release forms

Trimetazidine goes on sale in various forms, depending on the manufacturer its name differs:

• Teva;
• Biocom MV;
• Vero.

The tablets differ not only in the manufacturer, but also in the dosage of the active substance. Trimetazidine substance content:

• 20 mg;
• 35 mg;
• 80 mg.

It is important to note that tablets containing 80 mg of trimetazidine are marketed in the form of the drug Preductal OD. Indications for use – identical to Trimetazidine

An absolutely similar drug; in addition to trimetazidine, it contains auxiliary components:

• magnesium stearate;
• talc;
• hypromellose;
• ethylcellulose;
• tributyl acetyl citrate.

Price

Trimitazidine prices depend on the dosage of the active ingredient and the number of tablets in the package. The approximate cost of the drug depending on the manufacturer is presented in the table (Table 1).

Table 1 - Average prices for the drug Trimetazidine

The cost of the product may vary slightly depending on the region. The highest price was noted in Moscow and the Moscow region.

Side effects of the drug

Instructions for use of Urodan provide for the following side effects:

• Nausea;
• Pain in the stomach area.

In some cases, patients who have taken dietary supplements for a long time have experienced the following complications:

1. Problems with stool;
2. Tremor;
3. Headache;
4. Vomit.

If side effects occur, you should consult a doctor. A specialist will be able to select a worthy replacement for Urodan.

special instructions

The drug is not recommended to be used together with strong alcoholic drinks.

When used simultaneously with other drugs containing acetylsalicylic acid and quinidine, a decrease in Urodane is observed.

Impact on the ability to drive a car and operate machinery

Urodane does not affect the nervous system and psychomotor reactions when taken correctly. If there are side symptoms (tremor of the limbs, tonic convulsions), you should refrain from operating dangerous mechanisms.

Use in pediatrics

Urodane is prohibited from being used to treat children under fourteen years of age.

For liver dysfunction

The instructions do not contain any restrictions for taking the supplement for liver dysfunction. The list of contraindications does not include conditions associated with liver pathologies.

For abnormalities in kidney function

Urodane is intended for the treatment of pathologies of the kidneys and urinary system. There are no exceptions to the list of contraindications in the instructions.

Scheme for using "Urodan"

The product must be diluted with water before use. To do this, 1 teaspoon of powder is dissolved in 0.1 liter of liquid. The resulting product has a consistency similar to an effervescent suspension. The dietary supplement must be taken three times a day. If an attack of renal colic occurs, it is allowed to increase the frequency of taking Urodan to four times a day. The product is drunk thirty minutes before meals.

If there are appropriate indications, you can repeat the course again. In agreement with the doctor, “Urodan” is allowed to be used to prevent exacerbation of chronic kidney diseases.

Use during pregnancy

Urodane can be used during pregnancy, given the natural composition of the medicine. Before starting therapy, consult your doctor. The doctor will assess the risk to the fetus and the benefit to the mother and prescribe the necessary course of therapy.

Instructions for use

Urodan should be taken before eating, 1 teaspoon 3-4 times a day. The pre-granulated powder must be dissolved in warm boiled water to form a suspension (a teaspoon per ½ cup of water). You need to drink the entire suspension received (half a glass); a new solution should be prepared for the next dose.

Recommendations for use

Urodane is intended for oral administration (before meals).

The dietary supplement is taken 3-4 times a day, 1 teaspoon (after preliminary dissolution in 1/2 glass of water).

Instructions for use

An approximate scheme for using Urodan is described in detail in the instructions. The dosage and duration of taking the drug can be adjusted by your doctor. Additionally, the manufacturer explains the principle of the additive’s effect on the body, its composition and pharmacological properties.

Separate paragraphs of the instructions contain information about contraindications for taking the drug and possible side effects. Data on drug interactions, conditions and periods of storage of the supplement, and special instructions are described by the manufacturer in special sections.

pharmachologic effect

The main properties of Urodan are its disinfectant and anti-inflammatory effect. The action of the drug is aimed at normalizing kidney function and preventing the proliferation of pathogenic microbes in the urinary system.

The additive can provide good prevention of stone formation. In the presence of kidney stones, the drug accelerates the processes of their natural crushing and elimination from the body (only in combination with basic medications for the treatment of such conditions).

Pharmacological properties:

• improvement of the patient’s general condition during inflammatory processes in the urinary system;
• diuretic and diuretic effects;
• strengthening of redox processes;
• removal of excess uric acid from the body;
• harmful effects on pathogenic microorganisms;
• relief of inflammatory processes in the urinary system;
• beneficial effects on metabolic processes;
• normalization of potassium and glutathione levels in the blood;
• saturation of the tissues of the urinary system with oxygen;
• cleansing the flora of the urinary tract from products of the inflammatory process.

Release form and composition

Urodane is produced in the form of granulated powder for the preparation of a suspension, packaged in 100 ml plastic jars.

The active ingredients in the supplement are bearberry leaf extract, methenamine and piperazine. These substances provide the main pharmacological properties of the drug and have a beneficial effect on kidney function. The composition of the powder has been supplemented with auxiliary elements.

Excipients:

• tartaric acid;
• disodium phosphate.

Indications for use

Urodan contains a large amount of tannins and arbutin. These components have a disinfecting effect. The substances destroy pathogenic microorganisms, prevent their re-production and accelerate the process of restoration of the urinary system after suffering a pathology.

The drug can be used in inflammatory processes of various origins (including in the treatment of complications of other diseases manifested in impaired renal function).

Indications for use:

• gout therapy;
• chronic polyarthritis;
• symptoms of spondyloarthritis;
• salt deposition in the spine;
• neurourolithiasis;
• stones in the urinary system;
• inflammatory processes in the bladder.

Video: “Uurolithiasis: how to avoid?”

Directions for use and dosage

The standard therapeutic course of taking Urodan is limited to one month.

Before using the supplement, the powder should be dissolved in warm boiled water. For half a glass of liquid you will need one teaspoon of the drug. A new solution is prepared for each dose. The prepared suspension cannot be stored. The dosage and treatment regimen must be followed in accordance with the instructions or schedule drawn up by a specialist.

Reception regimen:

• It is recommended to take the supplement three or four times a day (a teaspoon in half a glass of water);
• The drug should be taken before eating (thirty minutes before meals).

Interaction with other drugs

Urodane has some nuances of drug interactions with other pharmaceuticals. Acetylsalicylic acid and preparations containing quinidine can neutralize the pharmacological properties of the additive. Urodan should not be combined with ethanol-based medications or drink alcohol during therapy.

Video: “What is gout: causes and symptoms”

Urodan: analogues

List of drug analogues:

• Urosin. The drug includes methenamine, lithium benzonate. The medicine copes with bacteria in the urinary tract, helps remove stones from the body;
• Blemaren. The drug is considered one of the best remedies for the treatment of nephrolithiasis. The active components of the drug help reduce acidity, remove calcium, and slow down the process of crystal formation. Effervescent pills are effective against uric acid and calcium oxalate stones;
• Atophan. The drug is aimed at reducing the concentration of uric acid in the body and removing the substance. The medicine also copes with attacks of moderate and moderate pain.

The selection of an analogue depends on the patient’s condition and the characteristics of the course of the disease. It is prohibited to take any analogue on your own; entrust the choice of treatment to a professional.

• Urosine;
• Atofan;
• Allomaron;
• Zinhofen;
• Colchicine;
• Blemaren.

Active ingredients: 2.6 g bearberry extract (leaves), 2.5 g piperazine, 0.3 g methenamine

Related components: disodium phosphate, tartaric acid, sugar.

The drug is in the form of a granular mixture intended to restore a suspension. Packaged in 100 ml jars made of plastic. In a cardboard box: 1 container, instructions for use.

Since the dietary supplement has not been registered, analogues are prescribed instead of Urodan. Which of them will be the most effective should be determined by the treating specialist.

Esparma (Germany)

Price: table thorn. (80 pcs.) – 1107 rub.

Drugs from the group of drugs for the treatment of nephrourolithiasis. Designed for alkalization of urine in the complex treatment of kidney pathologies, dissolution of uric acid stones, while taking cytostatics and drugs that enhance the excretion of uric acid, in dermatology - as a symptomatic drug for porphyria.

The medicine has a multicomponent composition: it contains potassium bicarbonate, citric acid, and sodium citrate.

The product is available in the form of effervescent tablets or granulates for dissolution in liquid. Taken as a foaming liquid.

Dosage and duration of use - according to individual indications.

Pros:

• Helps
• Normal taste
• Convenience of reception.

Flaws:

• High price
• Not the same effect as Urodan.

Uralit-U

Plantextract (Germany)

Price: (280 g) – 1030 rub.

Medicines based on potassium sodium hydrogen citrate. Developed for the treatment of urolithiasis and urine alkalization.

Available in the form of a granular mixture for preparing a solution. It is taken three times a day after meals, and the evening dosage should be lower than the morning and afternoon dosage. Can be used over a long course (from 1 month to six months).

Blémarin

One of the most popular medications after Urodan, which has a beneficial effect on reducing the acidity of urine.
The active ingredients of the product help reduce calcium excretion and slow down the process of stone formation. Blemaren is recommended to be taken for neafrolithiasis, since the drug affects the breakdown of stones.

Urosine

On the pharmacological market it is an analogue of Urodan. Prescribed for the same indications for use, available in tablets.

Atofan

This medication contains alkaline salts, which helps reduce the accumulation of uric acid and slows down the process of formation of salt stones.

Solimok

This product is recommended for use as a prophylactic against the formation of stones. Available in granular form, intended for the preparation of a suspension.

Cyston

The effect of the drug Cyston is due to the properties of the components included in its composition. Didymocarpus stem contains isopedicin, pedicin, essential oil, pedicillin. Has pronounced diuretic properties. 4.5(23) Diseases of the urinary system, Cystitis, Urethritis, Gout, Urinary incontinence.

Urisan

The dietary supplement Urisan has a positive effect on patients with uric acid metabolism disorders (gout) and kidney diseases. 4.9(52) Gout, Kidneys, Genitourinary system.

Diet therapy for gout

Diet plays an extremely important role in the treatment of gout. Often, strict adherence to the diet can even save the patient from gout attacks.

It is extremely important to completely abstain from drinking alcohol. This necessary condition must also be observed during treatment with Allopurinol. If there is no effect from treatment, then the patient drinks alcohol.

Exclude from food

recommended fatty meat, beef, offal (lungs, liver, kidneys, brains), meat, fish and mushroom broths, porcini mushrooms, peas, asparagus, fatty fish, sardines and sprats, smoked fish, herring, pork and cooking fat, cauliflower , spinach and sorrel.

Limit

desirable: consumption of coffee, strong tea, cocoa, chocolate, pastry and puff pastry products, sauces, ketchups, figs, fresh tomatoes, tomato paste and salt. The amount of fat consumed should be reduced, because... they reduce the secretion of uric acid. Vegetable oil and butter are allowed as fats. Low-fat varieties of meat and fish are allowed to be consumed boiled and lightly fried (1-2 times a week).

Allowed in food

various cereals, chicken eggs (1 per day), Swiss cheese, caviar, white and black bread, milk, sour cream, kefir, cottage cheese, walnuts and hazelnuts, potatoes, onions, radishes, eggplants, beans. Eating berries and fruits, such as oranges, grapes, lemon, cherries, dogwoods, blueberries, apples, strawberries, plums, pears, watermelon, is very beneficial. Fruits can be consumed both fresh and in the form of compotes, jelly, and fruit drinks. Seasonings allowed include lemon juice, bay leaf, vinegar, cinnamon, and vanillin.

Food should be taken in small portions, 5-6 times a day. Alkaline mineral water, rosehip decoction - drink between meals.

Patients suffering from gout are advised to control their weight. If you are overweight, then it is advisable to use fasting days 1-2 times a week. You can spend fruit and vegetable (1.5 kg), kefir (1-2 l) or cottage cheese-kefir (low-fat cottage cheese 400 g and kefir 500 ml) days. Complete fasting is not recommended.

The package contains 30 tablets of 500 mg. Active ingredient Probenecid. Manufacturer: Bouchara-Recordati, France. Our specialists will help you find the nearest pharmacy in Moscow, St. Petersburg, Yekaterinburg, Krasnoyarsk, Novosibirsk, Samara, Tyumen or Chelyabinsk, where you can buy Benemid. If your request comes from other regions, we will be able to help you individually.

See also: Probenecid tab. 500 mg No. 30, produced by Biokanol Pharma GmbH (Germany).

Benemid tablets produced by Bouchara-Recordati (France) are used to treat gout. They normalize the level of uric acid in the blood, as a result of which its crystals cease to form and are deposited in the joints in the form of specific nodules (tophi). The drug can also be used when taking penicillins and cephalosportins (with the exception of cephaloridine). The main active ingredient probenecid enhances the reabsorption of uric acid in the renal tubules. Its increased excretion from the body occurs, resulting in a uricosuric effect - a decrease in the concentration of uric acid in the blood. This prevents the deposition of urate in the kidneys and cartilage. Under the influence of the drug, uric acid from existing tophi can be released into the blood, which can provoke an acute gout attack. The maximum concentration in the blood is reached 3 hours after taking the drug. Excreted in urine.

Benemide tablets should not be taken if:

• pregnancy, lactation;
• urolithiasis;
• acute gout attack;
• secondary hyperuricemia caused by chemotherapeutic agents or tumor development;
• hypersensitivity to Probenecid and other components of the drug;
• patients with peripheral blood picture disorders;
• children under 2 years old;

Benemide tablets are taken according to the doctor's recommended regimen (usually twice a day), which often includes a gradual increase in dosage. After achieving a stable effect, the daily dose of the drug can be gradually reduced. While taking diuretics, it is recommended to increase the daily dose. If the drug is prescribed during antibiotic therapy, it should be taken in 4 doses half an hour before the administration of the antibiotic.

Before you buy Benemid at your nearest pharmacy, you should definitely consult your doctor. Self-medication is dangerous for your health.

People's opinion

Reviews in the medical field and from buyers vary. Some did not experience any results or effects from the course they took, but Urodan helped others well.

Reviews from doctors:

It should be borne in mind that the treatment of any inflammatory process, gout or urolithiasis requires a long period.

The treatment course includes taking medications, and any physiotherapeutic procedures, dietary nutrition and other methods according to the indications and characteristics of the disease and the general condition of the patient. The dietary supplement Urodan is in most cases recommended as an adjuvant to the main treatment.

This is a good proven remedy. Before use, be sure to consult with your doctor who knows your medical history. This is important to avoid side effects.

Arkady Ivanovich, doctor

It is known that increased levels of uric acid affect the formation of stones and the development of related diseases. The drug Urodan shows positive results in the treatment of gout and urolithiasis, removing excess acid.

In addition, chronic diseases require regular use of medications as a preventive measure against relapse of symptoms. Urodane is quite suitable for such purposes.

After taking Urodan, your overall health improves and the likelihood of relapse decreases.

Elena Alekseevna, doctor

Patient reviews:

I took a course of Urodan for the treatment of gout for more than a month. I didn’t notice any changes for the better or any effect. The main thing is that there were no side effects, which is also pleasing.

Alexey, 48 years old

People, the treatment of any disease should be comprehensive and you should not expect a miracle from taking this drug, especially a dietary supplement. She was treating gout and taking Urodan in combination with other medications prescribed by the doctor. Inflammation has decreased and health has improved.

Svetlana, 57 years old

A good drug, no side effects, easy to drink, quite pleasant, the instructions clearly explain how to use it. However, it is very difficult to get it; it is no longer sold in city pharmacies (the first time I bought it at a pharmacy). Tell me where can I buy it?

Vladislav, 32 years old

Pros and cons according to patient reviews

Most patients who took Urodan report positive results and good effects after completing the course. It was noticed that small stones gradually dissolved by the end of the course of taking the drug.

Among the disadvantages of patients, you can hear about the occurrence of adverse reactions. In this case, you should remember that there are contraindications to taking the drug.

URO-GYAL

URO-HYAL (manufactured in Russia) is a drug that protects the mucous layer of the urethra and bladder when instilled (dropped) into the latter.

Release forms

The drug is available in the form of a sterile solution of sodium hyaluronate (1 mg in 1 ml), hermetically sealed in a 50 ml bottle.

Use for cystitis

The main purpose of the drug URO-HYAL is cystitis:

• recurrent (chronic);
• interstitial;
• ray.

The URO-HYAL solution, previously brought to a temperature of about 20 degrees, is injected into the empty bladder through a urological catheter. The residence time of the drug in the bladder should not be less than half an hour.

The procedure is carried out once every seven days and requires repetition from 4 to 12 times. The treatment regimen with the drug is determined by the severity of the symptoms of the disease and is established individually.

Recommended regimen: up to 6 weeks per installation, then once every four weeks until the end of the course.

In this case, it is advisable to carry out a maintenance installation once a month so that the total duration of therapy is one year.

Description

URO-HYAL is a transparent sterile solution of sodium hyaluronate with a pH of 6.5 - 7.5, which according to physical characteristics is classified as viscoelastic (viscoelastic) liquids. Viscoelastic solutions are characterized by the ability to liquefy under external force, remaining stable upon repeated exposure.

Such solutions perform a protective (protective) function against sensitive tissue surfaces.

The therapeutic effect of a solution of hyaluronic acid salt is due to the following fact: this acid is part of the mucous layer lining the inner surface of the bladder and urethra, preventing bacteria from attaching to the walls of the organ.

When this layer is destroyed, bacteria are retained on the wall of the bladder, causing cystitis. When instilled, URO-HYAL restores the damaged layer, producing a therapeutic effect, and also forms a protective film on the mucous membrane, protecting it from external influences during various medical procedures.

Indications for use

• The need to create temporary protection for the bladder mucosa during medical procedures (cystoscopy, urethroscopy, radiation therapy of the pelvic organs, TUR of the bladder and prostate gland).
• Treatment of cystitis (recurrent/chronic, interstitial, radiation).
• Complex therapy (in combination with vanilloid receptor agonists and M-anticholinergics) for an overactive bladder.

Contraindications for use

• Individual expressed sensitivity to the components of the solution.
• Childhood.
• Pregnancy.
• Breastfeeding period.

special instructions

• Requires strict adherence to temperature conditions during storage.
• Intended exclusively for intravesical administration via a urological catheter performed by a physician.
• It is not compatible with quaternary ammonium salts, therefore the drug should not be allowed to come into contact with instruments that have been treated with such agents.